Comparing the Efficacy of Sequential and Standard Quadruple Therapy for Eradication of H. Pylori Infection.

Q3 Medicine

Acta medica (Hradec Kralove) Pub Date : 2020-01-01 DOI:10.14712/18059694.2020.61

Mohsen Razavizadeh, Abbas Arj, Maryam Madani, Hamidreza Gilassi

{"title":"Comparing the Efficacy of Sequential and Standard Quadruple Therapy for Eradication of H. Pylori Infection.","authors":"Mohsen Razavizadeh, Abbas Arj, Maryam Madani, Hamidreza Gilassi","doi":"10.14712/18059694.2020.61","DOIUrl":null,"url":null,"abstract":"Background: The aim of this study was comparison the effectiveness of sequential and standard quadruple therapy on eradication of H. pylori infection.Methods: This clinical trial study was conducted on 160 patients with dyspepsia or gastroduodenal ulcer. Patients were randomly divided into two groups. Group A (standard regimen) received omeprazole, amoxicillin, clarithromycin and bismuth subcitrate for 2 weeks. Group B (sequential regimen) received omeprazole and amoxicillin in 5 days and omeprazole, tinidazole and levofloxacin in 5 days. After the end of treatment regimens, 20 mg omeprazole was administered twice daily for 3 weeks. H. pylori eradication was assessed 2 months after antibiotic treatment via fecal antigen.Results: Frequency of H. pylori eradication in group A and B was observed in 55 (68.8%) and 63 patients (78.8%), respectively. No significant difference was seen between two groups, regarding H. pylori eradication (p = 0.15). The most common side effects in group A, B were bitterness of mouth (63.8%) and nausea (16.2%), respectively (p H. pylori infection, higher rate of H. pylori eradication was seen in group B than group A. Thus, sequential regimen was a more appropriate regimen with fewer complications.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta medica (Hradec Kralove)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14712/18059694.2020.61","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 2

Abstract

Background: The aim of this study was comparison the effectiveness of sequential and standard quadruple therapy on eradication of H. pylori infection.

Methods: This clinical trial study was conducted on 160 patients with dyspepsia or gastroduodenal ulcer. Patients were randomly divided into two groups. Group A (standard regimen) received omeprazole, amoxicillin, clarithromycin and bismuth subcitrate for 2 weeks. Group B (sequential regimen) received omeprazole and amoxicillin in 5 days and omeprazole, tinidazole and levofloxacin in 5 days. After the end of treatment regimens, 20 mg omeprazole was administered twice daily for 3 weeks. H. pylori eradication was assessed 2 months after antibiotic treatment via fecal antigen.

Results: Frequency of H. pylori eradication in group A and B was observed in 55 (68.8%) and 63 patients (78.8%), respectively. No significant difference was seen between two groups, regarding H. pylori eradication (p = 0.15). The most common side effects in group A, B were bitterness of mouth (63.8%) and nausea (16.2%), respectively (p H. pylori infection, higher rate of H. pylori eradication was seen in group B than group A. Thus, sequential regimen was a more appropriate regimen with fewer complications.

查看原文本刊更多论文

顺序四联疗法与标准四联疗法根除幽门螺杆菌感染的疗效比较。

背景:本研究的目的是比较顺序和标准四联疗法根除幽门螺杆菌感染的有效性。方法:对160例消化不良或胃十二指肠溃疡患者进行临床试验研究。患者随机分为两组。A组(标准方案)给予奥美拉唑、阿莫西林、克拉霉素、亚柠檬酸铋治疗，疗程2周。B组(序贯方案)分别给予奥美拉唑、阿莫西林5 d和奥美拉唑、替硝唑、左氧氟沙星5 d。治疗方案结束后，给予奥美拉唑20 mg，每日2次，连续3周。在抗生素治疗2个月后通过粪便抗原评估幽门螺杆菌根除情况。结果:A、B组幽门螺杆菌根除率分别为55例(68.8%)和63例(78.8%)。在幽门螺杆菌根除方面，两组间无显著差异(p = 0.15)。A、B组最常见的不良反应分别为口腔苦味(63.8%)和恶心(16.2%)(p幽门螺杆菌感染，B组幽门螺杆菌根除率高于A组)，因此，顺序方案是更合适的方案，并发症更少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta medica (Hradec Kralove) Medicine-Medicine (all)

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： Acta Medica (Hradec Králové) is a multidisciplinary medical journal published by the Faculty of Medicine in Hradec Králové - Karolinum Press, the publishing house of Charles University. The journal is peer-reviewed and published quarterly in both paper and electronic form. The language of Acta Medica is English. Offerings include review articles, original articles, brief communications, case reports, announcements and notices. The journal was founded in 1958 under the title "A Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove."