Negar Moradian, Mahdi Gouravani, Mohammad Amin Salehi, Arash Heidari, Melika Shafeghat, Michael R Hamblin, Nima Rezaei
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引用次数: 37
Abstract
Coronavirus disease (COVID-19) reached pandemic proportions at the beginning of 2020 and continues to be a worldwide concern. End organ damage and acute respiratory distress syndrome are the leading causes of death in severely or critically ill patients. The elevated cytokine levels in severe patients in comparison with mildly affected patients suggest that cytokine release syndrome (CRS) occurs in the severe form of the disease. In this paper, the significant role of pro-inflammatory cytokines, including IL-1, IL-6, and TNF-alpha, and their mechanism of action in the CRS cascade is explained. Potential therapeutic approaches involving anti-IL-6 and anti-TNF-alpha antibodies to fight COVID-19 and reduce mortality rate in severe cases are also discussed.
期刊介绍：
The journal that brings together all areas of work involving cytokines.
European Cytokine Network is an electronic journal that publishes original articles and abstracts every quarter to provide an essential bridge between researchers and clinicians with an interest in this cutting-edge field.
The journal has become a must-read for specialists in the field thanks to its swift publication and international circulation.
The journal is referenced in several databases, including Medline, which is testament to its scientific quality.
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