The "Dark Side" of Pneumoperitoneum and Laparoscopy.

IF 1.3 Q3 SURGERY
Minimally Invasive Surgery Pub Date : 2021-05-19 eCollection Date: 2021-01-01 DOI:10.1155/2021/5564745
Giuseppina Rosaria Umano, Giulia Delehaye, Carmine Noviello, Alfonso Papparella
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引用次数: 12

Abstract

Laparoscopic surgery has been one of the most common procedures for abdominal surgery at pediatric age during the last few decades as it has several advantages compared to laparotomy, such as shorter hospital stays, less pain, and better cosmetic results. However, it is associated with both local and systemic modifications. Recent evidence demonstrated that carbon dioxide pneumoperitoneum might be modulated in terms of pressure, duration, temperature, and humidity to mitigate and modulate these changes. The aim of this study is to review the current knowledge about animal and human models investigating pneumoperitoneum-related biological and histological impairment. In particular, pneumoperitoneum is associated with local and systemic inflammation, acidosis, oxidative stress, mesothelium lining abnormalities, and adhesion development. Animal studies reported that an increase in pressure and time and a decrease in humidity and temperature might enhance the rate of comorbidities. However, to date, few studies were conducted on humans; therefore, this research field should be further investigated to confirm in experimental models and humans how to improve laparoscopic procedures in the spirit of minimally invasive surgeries.

Abstract Image

Abstract Image

Abstract Image

气腹和腹腔镜的“阴暗面”。
在过去的几十年里,腹腔镜手术一直是儿科腹部手术中最常见的手术之一,因为与剖腹手术相比,腹腔镜手术有几个优点,比如住院时间更短,疼痛更少,美容效果更好。然而,它与局部和系统的变化有关。最近的证据表明,二氧化碳气腹可以在压力、持续时间、温度和湿度方面进行调节,以减轻和调节这些变化。本研究的目的是回顾目前关于研究气腹相关生物学和组织学损伤的动物和人类模型的知识。特别是,气腹与局部和全身炎症、酸中毒、氧化应激、间皮内膜异常和粘连发展有关。动物研究报告说,压力和时间的增加以及湿度和温度的降低可能会增加合并症的发生率。然而,迄今为止,对人类进行的研究很少;因此,这一研究领域有待进一步研究,以实验模型和人体验证如何在微创手术的精神下改进腹腔镜手术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.00
自引率
0.00%
发文量
8
审稿时长
16 weeks
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