{"title":"A biography of the point contact fixator (PC-Fix).","authors":"S Tepic, S Bresina","doi":"10.22203/eCM.v041a41","DOIUrl":null,"url":null,"abstract":"<p><p>Starting in the mid-eighties, the AO (from the German \"Arbeitsgemeinschaft für Osteosynthesefragen\") Research Institute (ARI), Davos, Switzerland together with the commercial partners of the AO Foundation embarked on a decade-long project to design, develop, test in experimental animals and human clinical trials as well as bring to clinical use a new system for surgical osteosynthesis. The new plating system, what became known as the Point Contact Fixator (PC-Fix), addressed the shortcomings of the conventional plating by Dynamic Compression Plate (DCP) discovered either by careful examination of the clinical complications or by chance observation and informed inquiry in experimental animals. The focus was on avoiding iatrogenic damage to bone vascularisation caused by the implant design and mechanical function and, thus, aiding efforts of surgeons to preserve vital bone tissue needed for healing. Infections have been and will remain a great concern in all surgery. Preservation of blood perfusion of traumatised bone is of paramount importance to reduce the risk of infection, especially in view of the emergence and the accelerated spread of bacterial resistance to antibiotics. Prof. Stephan Perren led this project in all its stages with his unique insight and wisdom. Unfortunately, due to the complex interplay of factors guiding the interests of the AO Foundation and its commercial partners, the findings of the PC-Fix project became watered down with implant systems that followed the DCP. The message of \"keep the perfusion\" faded into \"lock the screws\". The potential benefits of PC-Fix have been lost for millions of trauma patients.</p>","PeriodicalId":11849,"journal":{"name":"European cells & materials","volume":" ","pages":"633-647"},"PeriodicalIF":3.1000,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European cells & materials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.22203/eCM.v041a41","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}
引用次数: 0
Abstract
Starting in the mid-eighties, the AO (from the German "Arbeitsgemeinschaft für Osteosynthesefragen") Research Institute (ARI), Davos, Switzerland together with the commercial partners of the AO Foundation embarked on a decade-long project to design, develop, test in experimental animals and human clinical trials as well as bring to clinical use a new system for surgical osteosynthesis. The new plating system, what became known as the Point Contact Fixator (PC-Fix), addressed the shortcomings of the conventional plating by Dynamic Compression Plate (DCP) discovered either by careful examination of the clinical complications or by chance observation and informed inquiry in experimental animals. The focus was on avoiding iatrogenic damage to bone vascularisation caused by the implant design and mechanical function and, thus, aiding efforts of surgeons to preserve vital bone tissue needed for healing. Infections have been and will remain a great concern in all surgery. Preservation of blood perfusion of traumatised bone is of paramount importance to reduce the risk of infection, especially in view of the emergence and the accelerated spread of bacterial resistance to antibiotics. Prof. Stephan Perren led this project in all its stages with his unique insight and wisdom. Unfortunately, due to the complex interplay of factors guiding the interests of the AO Foundation and its commercial partners, the findings of the PC-Fix project became watered down with implant systems that followed the DCP. The message of "keep the perfusion" faded into "lock the screws". The potential benefits of PC-Fix have been lost for millions of trauma patients.
从八十年代中期开始,位于瑞士达沃斯的AO(来自德国“Arbeitsgemeinschaft f r osteosynthesis efragen”)研究所(ARI)与AO基金会的商业合作伙伴一起开始了一项长达十年的项目,旨在设计、开发、在实验动物和人体临床试验中进行测试,并将一种新的手术骨合成系统投入临床使用。新的电镀系统,后来被称为点接触固定器(PC-Fix),通过仔细检查临床并发症或在实验动物中偶然观察和询问发现的动态加压钢板(DCP),解决了传统电镀的缺点。重点是避免由植入物设计和机械功能引起的医源性骨血管损伤,从而帮助外科医生保护愈合所需的重要骨组织。在所有的外科手术中,感染一直是并将继续是一个很大的问题。保存损伤骨的血液灌注对于降低感染风险至关重要,特别是考虑到细菌对抗生素的耐药性的出现和加速传播。Stephan Perren教授以其独特的洞察力和智慧领导了这个项目的各个阶段。不幸的是,由于引导AO基金会及其商业伙伴利益的因素的复杂相互作用,PC-Fix项目的发现被DCP之后的植入系统冲淡了。“保持灌注”的信息变成了“锁紧螺丝”。数以百万计的创伤患者已经失去了PC-Fix的潜在好处。
期刊介绍:
eCM provides an interdisciplinary forum for publication of preclinical research in the musculoskeletal field (Trauma, Maxillofacial (including dental), Spine and Orthopaedics).
The clinical relevance of the work must be briefly mentioned within the abstract, and in more detail in the paper. Poor abstracts which do not concisely cover the paper contents will not be sent for review. Incremental steps in research will not be entertained by eCM journal.Cross-disciplinary papers that go across our scope areas are welcomed.