Dynamic mechanism of multiple bursting patterns in a whole-cell multiscale model with calcium oscillations.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-12-01 DOI:10.1080/17513758.2021.1925753

Xiaowen Xiong, Yanqiu Li, Dongmei Zheng

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引用次数: 1

Abstract

The dynamic mechanism of a whole-cell model containing electrical signalling and two-compartment Ca $^{2 +}$ signalling in gonadotrophs is investigated. The transition from spiking to bursting by Hopf bifurcation of the fast subsystem about the slow variable is detected via the suitable parameters. When the timescale of K $^{+}$ gating variable is changed, the relaxation oscillation with locally small fluctuation, chaotic bursting and mixed-mode bursting (MMB) are revealed through chaos. In addition, the bifurcation of $[{C a}^{2 +}]_{i}$ with regard to $[I P_{3}]$ is analysed, showing periodic solutions, torus, period doubling solutions and chaos. Finally, hyperpolarizations and torus canard-like behaviours of the full system under a set of specific parameters are elucidated.

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含钙振荡的全细胞多尺度模型中多种破裂模式的动力机制。

研究了促性腺激素中含有电信号和双室Ca2+信号的全细胞模型的动态机制。通过适当的参数检测快子系统关于慢变量的Hopf分岔从尖峰到爆发的转变。当K+门控变量的时间尺度改变时，通过混沌表现出局域小波动的松弛振荡、混沌爆破和混合模式爆破(MMB)。此外，分析了[Ca2+]i对[IP3]的分岔，显示了周期解、环面、周期加倍解和混沌。最后，在一组特定参数下，阐明了整个系统的超极化和环面鸭状行为。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.