Treatment and outcomes for early non-small-cell lung cancer: a retrospective analysis of a Portuguese hospital database.

Pub Date : 2021-02-19 DOI:10.2217/lmt-2020-0028

Marta Soares, Luís Antunes, Patrícia Redondo, Marina Borges, Ruben Hermans, Dony Patel, Fiona Grimson, Robin Munro, Carlos Chaib, Laure Lacoin, Melinda Daumont, John R Penrod, John C O'Donnell, Maria José Bento, Francisco Rocha Gonçalves

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引用次数: 1

Abstract

Aim: This observational study evaluated treatment patterns and survival for patients with stage I-IIIA non-small-cell lung cancer (NSCLC).

Materials & methods: Adults newly diagnosed with NSCLC in 2012-2016 at IPO-Porto hospital were included. Treatment data were available for patients diagnosed in 2015-2016.

Results: 495 patients were included (median age: 67 years). The most common treatments were surgery alone or with another therapy (stage I: 66%) and systemic anticancer therapy plus radiotherapy (stage II: 54%; stage IIIA: 59%). One-year OS (95% CI) for patients with stage I, II and IIIA NSCLC (diagnosed 2012-2016) were 92% (88-96), 71% (62-82) and 69% (63-75), respectively; one-year OS (95% CI) for treated patients with stage I-II or stage IIIA NSCLC (diagnosed 2015-2016) were 89% (81-97) and 86% (75-98) for non-squamous cell and 76% (60-95) and 49% (34-70) for squamous cell NSCLC.

Conclusion: Treatment advances are strongly needed for stage I-IIIA NSCLC, especially for patients with squamous cell histology.

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早期非小细胞肺癌的治疗和结果:对一家葡萄牙医院数据库的回顾性分析。

目的:本观察性研究评估I-IIIA期非小细胞肺癌(NSCLC)患者的治疗模式和生存率。材料与方法:纳入2012-2016年IPO-Porto医院新诊断为NSCLC的成人。2015-2016年诊断的患者可获得治疗数据。结果:纳入495例患者(中位年龄:67岁)。最常见的治疗方法是单独手术或联合其他治疗(I期:66%)和全身抗癌治疗加放疗(II期:54%;IIIA期:59%)。I期、II期和IIIA期NSCLC(2012-2016年诊断)患者的1年OS (95% CI)分别为92%(88-96)、71%(62-82)和69% (63-75);接受治疗的I-II期或IIIA期NSCLC(2015-2016年诊断)患者的一年OS (95% CI)，非鳞状细胞为89%(81-97)和86%(75-98)，鳞状细胞NSCLC为76%(60-95)和49%(34-70)。结论:迫切需要I-IIIA期NSCLC的治疗进展，特别是对鳞状细胞组织学的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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