Biomarkers in Cystic Fibrosis Lung Disease - A Review.

Abstract

Cystic fibrosis is a polymorphic disease, marked by multiple and difficult-to-treat respiratory exacerbations with severe evolution. The lung disease dictates the disease's evolution and it must be diagnosed early and treated accordingly, but the diagnosis is sometimes challenging because of the lack of a sensible tool. In the era of the biomarkers, the need for a sensitive and reliable one would be extremely important, considering that inflammation secondary to infections produce irreversible structural changes in the cystic fibrosis lungs. The present paper reviews the studied biomarkers in inflammation and infection with potential role in cystic fibrosis lung disease.