Bactériémies Nosocomiales: Épidémiologie Clinique Et Bactériologique Chez Les Brûlés.

Q3 Medicine

Annals of burns and fire disasters Pub Date : 2021-03-31

S Frigui, Y Bourbiaa, A Mokline, H Naija, A A Messadi, L Thabet

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引用次数: 0

Abstract

Nosocomial bacteremia (NB) is one of the most severe infections in burns in intensive care units. Their prognosis is worsened with the emergence and spread of multidrug resistant bacteria (MDR). Our retrospective study aimed to investigate clinical and bacteriological characteristics of NB occurring in patients hospitalized in the Trauma and Burn Center's Burn Unit (TBC-BU) in Tunisia, during a 3-year period (2016-2018). We found 261 NB in 216 patients, for a prevalence of 25.7% and an incidence density of 13.4‰ days of in-patient stay. The vast majority (88.9%) of NB occurred during the first 2 weeks of hospitalization. The catheterrelated bacteremia rate was 11.1%. P. æruginosa (20.2%) and A. baumannii (16.8%) were the 2 species most frequently isolated when S. aureus represented only 7.5% of isolates. Resistance rates were high, with 71% of P. æruginosa resistant to ceftazidime, 64% of S. aureus being MRSA, 69,5% of resistance to 3rd generation cephalosporins among Enterobacteriaceae, and colimycin remaining the only regularly active antibiotic (98%) on A. baumannii. The MDR rate was 44%, represented mainly by A. baumannii, ESBL-E and P. æruginosa. The mortality rate due to NB was 25%, with a significantly higher rate of MDR in fatal NB compared to that in NB with favorable outcome (p = 0,000019).

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医院细菌学:烧伤患者的临床和细菌学流行病学。

院内菌血症(NB)是重症监护病房烧伤中最严重的感染之一。随着耐多药细菌(MDR)的出现和传播，其预后恶化。我们的回顾性研究旨在调查突尼斯创伤和烧伤中心烧伤部(TBC-BU)住院患者在3年(2016-2018)期间发生的NB的临床和细菌学特征。我们在216例患者中发现261例NB，患病率为25.7%，发病率密度为13.4‰。绝大多数NB(88.9%)发生在住院前2周。导管相关菌血症发生率为11.1%。P. ruginosa(20.2%)和A. baumannii(16.8%)是最常见的2种，金黄色葡萄球菌仅占分离株的7.5%。耐药率较高，71%的P. ruginosa对头孢他啶耐药，64%的金黄色葡萄球菌对MRSA耐药，69.5%的肠杆菌科病原菌对第三代头孢菌素耐药，而colimycin是鲍曼不动杆菌唯一的常规有效抗生素(98%)。耐多药率为44%，以鲍曼杆菌、ESBL-E和P. æruginosa为主。NB的死亡率为25%，致死性NB的MDR率明显高于预后良好的NB (p = 0,000019)。

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来源期刊

Annals of burns and fire disasters Nursing-Emergency Nursing

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： "Annals of Burns and Fire Disasters" is the official publication of the Euro-Mediterranean Council for Burns and Fire Disasters (MBC) and the European Burns Association (EBA). It is a peer-reviewed journal directed to an audience of medical as well as paramedical personnel involved in the management of burn injuries. The journal publishes original articles in the form of clinical and basic research, scientific advances. It publishes also selected abstracts from international journals.