Comparison of Insulins Glargine and Degludec in Diabetic Rhesus Macaques (Macaca mulatta) with CGM Devices.

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Comparative medicine Pub Date : 2021-06-01 Epub Date: 2021-05-25 DOI:10.30802/AALAS-CM-20-000075
Samantha C Puglisi, Alexis L Mackiewicz, Amir Ardeshir, Laura M Garzel, Kari L Christe
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引用次数: 1

Abstract

Treating and monitoring type 2 diabetes mellitus (T2DM) in NHP can be challenging. Multiple insulin and hypoglycemic therapies and management tools exist, but few studies demonstrate their benefits in a NHP clinical setting. The insulins glargine and degludec are long-acting insulins; their duration of action in humans exceeds 24 and 42 h, respectively. In the first of this study's 2 components, we evaluated whether insulin degludec could be dosed daily at equivalent units to glargine to achieve comparable blood glucose (BG) reduction in diabetic rhesus macaques (Macaca mulatta) with continuous glucose monitoring (CGM) devices. The second component assessed the accuracy of CGM devices in rhesus macaques by comparing time-stamped CGM interstitial glucose values, glucometer BG readings, and BG levels measured by using an automated clinical chemistry analyzer from samples that were collected at the beginning and end of each CGM device placement. The CGM devices collected a total of 21,637 glucose data points from 6 diabetic rhesus macaques that received glargine followed by degludec every 24 h for 1 wk each. Ultimately, glucose values averaged 29 mg/dL higher with degludec than with glargine. Glucose values were comparable between the CGM device, glucometer, and chemistry analyzer, thus validating that CGM devices as reliable for measuring BG levels in rhesus macaques. Although glargine was superior to degludec when given at the same dose (units/day), both are safe and effective treatment options. Glucose values from CGM, glucometers, and chemistry analyzers provided results that were analogous to BG values in rhesus macaques. Our report further highlights critical clinical aspects of using glargine as compared with degludec in NHP and the benefits of using CGM devices in macaques.

糖尿病恒河猴(Macaca mulatta)使用CGM装置时甘精胰岛素和去gludec的比较。
治疗和监测NHP患者的2型糖尿病(T2DM)具有挑战性。存在多种胰岛素和低血糖治疗和管理工具,但很少有研究表明它们在NHP临床环境中的益处。甘精胰岛素和降葡萄糖胰岛素是长效胰岛素;它们在人体内的作用时间分别超过24和42小时。在本研究的第一个部分中,我们评估了糖尿病恒河猴(Macaca mulatta)是否可以使用连续血糖监测(CGM)装置,以等值单位每日给药去葡萄糖糖胰岛素(insulin degludec)以达到与甘精相当的血糖(BG)降低效果。第二部分评估了恒河猴CGM装置的准确性,通过比较时间标记的CGM间质葡萄糖值、血糖仪BG读数,以及使用自动临床化学分析仪从每次CGM装置放置开始和结束时收集的样本中测量的BG水平。CGM装置从6只糖尿病恒河猴身上收集了21,637个葡萄糖数据点,这些恒河猴每24小时接受甘精氨酸和去gludec治疗,每个治疗1周。最终,葡萄糖值平均比甘精高29 mg/dL。葡萄糖值在CGM装置、血糖仪和化学分析仪之间具有可比性,从而验证了CGM装置是测量恒河猴血糖水平的可靠方法。虽然甘精在相同剂量(单位/天)下优于去gludec,但两者都是安全有效的治疗选择。CGM、血糖仪和化学分析仪提供的血糖值与恒河猴的血糖值相似。我们的报告进一步强调了在NHP中使用甘精与degludec相比的关键临床方面,以及在猕猴中使用CGM装置的好处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Comparative medicine
Comparative medicine 医学-动物学
CiteScore
1.90
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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