Yolanda Hagar, David Albers, Rimma Pivovarov, Herbert Chase, Vanja Dukic, Noémie Elhadad
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Abstract
This paper presents a detailed survival analysis for chronic kidney disease (CKD). The analysis is based on the EHR data comprising almost two decades of clinical observations collected at New York-Presbyterian, a large hospital in New York City with one of the oldest electronic health records in the United States. Our survival analysis approach centers around Bayesian multiresolution hazard modeling, with an objective to capture the changing hazard of CKD over time, adjusted for patient clinical covariates and kidney-related laboratory tests. Special attention is paid to statistical issues common to all EHR data, such as cohort definition, missing data and censoring, variable selection, and potential for joint survival and longitudinal modeling, all of which are discussed alone and within the EHR CKD context.
期刊介绍：
Statistical Analysis and Data Mining addresses the broad area of data analysis, including statistical approaches, machine learning, data mining, and applications. Topics include statistical and computational approaches for analyzing massive and complex datasets, novel statistical and/or machine learning methods and theory, and state-of-the-art applications with high impact. Of special interest are articles that describe innovative analytical techniques, and discuss their application to real problems, in such a way that they are accessible and beneficial to domain experts across science, engineering, and commerce.
The focus of the journal is on papers which satisfy one or more of the following criteria:
Solve data analysis problems associated with massive, complex datasets
Develop innovative statistical approaches, machine learning algorithms, or methods integrating ideas across disciplines, e.g., statistics, computer science, electrical engineering, operation research.
Formulate and solve high-impact real-world problems which challenge existing paradigms via new statistical and/or computational models
Provide survey to prominent research topics.
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