Association between insulin-like growth factor 1 and pancreatic volume in type 1 and type 2 diabetes: cross-sectional study of a Japanese population

IF 1.6 4区医学 Q4 CELL BIOLOGY

Growth Hormone & Igf Research Pub Date : 2021-08-01 DOI:10.1016/j.ghir.2021.101396

Tomoyasu Fukui , Ayako Fukase , Hiroto Sasamori , Makoto Ohara , Yusaku Mori , Michishige Terasaki , Munenori Hiromura , Hideki Kushima , Tetsuro Kobayashi , Sho-ichi Yamagishi

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引用次数: 2

Abstract

Aims/hypothesis

Although IGF-1 is known to promote organ growth, including exocrine pancreas, the association between plasma IGF-1 levels and pancreatic size remains unclear in diabetic patients.

Methods

This cross-sectional study was designed to investigate the correlations among pancreatic volume (PV) based on computed tomography, IGF-1 levels, age- and sex-adjusted IGF-1 levels (IGF-1 Z-score), and C-peptide levels in patients with type 1 diabetes (T1D) (n = 51) and type 2 diabetes (T2D) (n = 104) in a Japanese population.

Results

PV was significantly correlated with body weight (BW) in both types of diabetes. PV adjusted for BW (PV/BW), IGF-1 Z-score and C-peptide levels were significantly lower in patients with T1D than T2D. There was a significant positive correlation between C-peptide levels and PV/BW in both subtypes of diabetes. IGF-1 Z-scores were significantly correlated with PV/BW in patients with T1D (r = 0.37, P = 0.007), but not T2D. Although IGF-1 Z-scores were not correlated with age, age of disease onset, disease duration, HbA1c, or C-peptide levels in both types of diabetes, a multivariable liner regression analysis revealed that IGF-1 Z-score and C-peptide levels were independent correlates of PV/BW in T1D patients, while C-peptide levels were a sole correlate in T2D.

Conclusions/interpretation

Decreased IGF-1 levels might be one causal factor for smaller pancreas in patients with T1D.

查看原文本刊更多论文

1型和2型糖尿病患者胰岛素样生长因子1与胰腺体积的关系:日本人群的横断面研究

目的/假设虽然已知IGF-1促进器官生长，包括外分泌胰腺，但糖尿病患者血浆IGF-1水平与胰腺大小之间的关系尚不清楚。方法本横断面研究旨在探讨日本人群中1型糖尿病(T1D) (n = 51)和2型糖尿病(T2D) (n = 104)患者胰腺体积(PV)、IGF-1水平、年龄和性别调整的IGF-1水平(IGF-1 Z-score)和c肽水平之间的相关性。结果两型糖尿病患者的spv均与体重(BW)显著相关。T1D患者经体重调整后的PV (PV/BW)、IGF-1 Z-score和c肽水平均显著低于T2D患者。在两种糖尿病亚型中，c肽水平与PV/BW呈显著正相关。T1D患者IGF-1 z评分与PV/BW显著相关(r = 0.37, P = 0.007)，而T2D患者无显著相关。虽然IGF-1 z -评分与两种糖尿病患者的年龄、发病年龄、病程、HbA1c或c肽水平无关，但多变量线性回归分析显示，IGF-1 z -评分和c肽水平是T1D患者PV/BW的独立相关因素，而c肽水平是T2D患者的唯一相关因素。结论/解释IGF-1水平降低可能是T1D患者胰腺变小的一个原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Growth Hormone & Igf Research 医学-内分泌学与代谢

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

57 days

期刊介绍： Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.