Sleep Spindles and Auditory Sensory Gating: Two Measures of Cerebral Inhibition in Preschool-Aged Children are Strongly Correlated.

Colorado journal of psychiatry & psychology Pub Date : 2017-01-01

Peng-Peng Wei, Sharon K Hunter, Randal G Ross

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Abstract

Introduction: Sleep spindles and P50 sensory gating are both reflective of cerebral inhibition, however, are differentially active during different phases of sleep. Assessing whether sleep spindles and P50 sensory gating correlate is a first step to evaluate whether these 2 forms of cerebral inhibition reflect overlapping neural circuits.

Methods: EEG data were collected between midnight and 6:00 AM on 13 healthy preschool-aged children. P50 sensory gating, calculated during REM sleep, negatively correlated with spindle duration (r=-.715, p=.006) and inter-peak density (r=.744, p=.004). There was a trend toward higher S2/S1 ratios being associated with fewer peaks per spindle (r=-.546, p=.053). In 4-year-olds, 2 established physiological measures of sensory gating and are correlated despite being maximally active during different stages of sleep.

Conclusions: These results suggest there is an overlap in brain mechanisms underlying each gating mechanism.

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睡眠纺锤波与听觉门控:学龄前儿童大脑抑制的两项指标密切相关。

睡眠纺锤波和P50感觉门控都是大脑抑制的反映，但在不同的睡眠阶段，它们的活性是不同的。评估睡眠纺锤波和P50感觉门控是否相关是评估这两种形式的大脑抑制是否反映重叠神经回路的第一步。方法:采集13例健康学龄前儿童午夜至上午6时的脑电图数据。在快速眼动睡眠期间计算的P50感觉门控与纺锤波持续时间呈负相关(r=-)。715, p=.006)，峰间密度(r=。744年,p = 04)。S2/S1比值越高，每轴峰数越少(r=-)。546年,p = .053)。在4岁的孩子中，2建立了感觉门控的生理测量，尽管在不同的睡眠阶段最活跃，但它们是相关的。结论:这些结果表明，每种门控机制背后的脑机制存在重叠。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Colorado journal of psychiatry & psychology

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