Association of angiotensin-converting enzyme gene insertion/deletion polymorphism and obstructive sleep apnoea in a Chinese population: A meta-analysis.

IF 2.1 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2020-06-17 eCollection Date: 2020-04-01 DOI:10.1177/1470320320934716
Jian Xu, Jiming Chen, Yilu Li, Dandan Zhang, Xiaoli Li
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引用次数: 1

Abstract

Introduction: Many studies have investigated the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and susceptibility to obstructive sleep apnoea (OSA). However, few have confirmed the relationship between ACE and OSA in the Chinese population. We performed a meta-analysis of studies relating the ACE I/D polymorphism to the risk of OSA in a Chinese population.

Methods: We evaluated eligible published studies from several databases for this meta-analysis. Subgroup analyses were performed for hypertension. Pooled odds ratios and 95% confidence intervals were calculated using a fixed- or random-effects model.

Results: Ten studies were identified to analyse the association between ACE I/D polymorphism and OSA risk. No marked associations were found in any genetic model (p>0.05). Subgroup analysis showed an association with hypertension (D vs. I, DD vs. II, ID vs. DD+II, DD+ID vs. II, ID vs. II; p<0.05), which was confirmed by sensitivity analyses. No obvious publication bias was found using Egger's test (p>0.05).

Conclusions: The ACE I/D polymorphism was not associated with an increased risk of OSA in a Chinese population. However, within the hypertensive subgroup, we detected a significant association between the ACE polymorphism and OSA. More case-control investigations are required.

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中国人群中血管紧张素转换酶基因插入/缺失多态性与阻塞性睡眠呼吸暂停的关联:一项荟萃分析
许多研究探讨了血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性与阻塞性睡眠呼吸暂停(OSA)易感性之间的关系。然而,很少有人证实ACE与OSA在中国人群中的关系。我们对中国人群中ACE I/D多态性与OSA风险相关的研究进行了荟萃分析。方法:我们从几个数据库中评估了符合条件的已发表研究。对高血压进行亚组分析。合并优势比和95%置信区间使用固定或随机效应模型计算。结果:10项研究分析了ACE I/D多态性与OSA风险的关系。各遗传模型均无显著相关性(p>0.05)。亚组分析显示与高血压相关(D vs. I, DD vs. II, ID vs. DD+II, DD+ID vs. II, ID vs. II;页> 0.05)。结论:在中国人群中,ACE I/D多态性与OSA风险增加无关。然而,在高血压亚组中,我们发现ACE多态性与OSA之间存在显著关联。需要进行更多的病例对照调查。
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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
16
审稿时长
6-12 weeks
期刊介绍: JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.
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