The Effects of Ranitidine Treatment on the Risk of Necrotizing Enterocolitis in Preterm Infants: A Case-Control Study.

Q3 Medicine

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI:10.14712/18059694.2021.2

Zlatan Zvizdic, Emir Milisic, Asmir Jonuzi, Sabina Terzic, Denisa Zvizdic, Semir Vranic

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引用次数: 2

Abstract

Introduction: Gastric acidity plays an important role in the protection of infants against various pathogens from the environment. The histamine-2 receptor blockers (H2-blockers) are off-labeled drugs that are frequently prescribed in preterm neonates to prevent stress ulcers. The impact of the H2-blockers on the development of the necrotizing enterocolitis (NEC) in preterm infants is still controversial, particularly in the developing world.

Materials and methods: One hundred twenty-two preterm infants were enrolled in the study. The multivariate logistic regression model was used to identify potential postnatal risk factors associated with NEC.

Results: Preterm infants (n = 51) with total NEC, medical NEC, and surgical NEC had the highest rate of receiving ranitidine compared with controls (n = 71) (39.2%, 19.6%, and 47.6%, p < 0.05). Logistic regression analysis revealed that ranitidine use and nosocomial infections were significantly associated with NEC development (odds ratios 1.55 and 3.3).

Conclusions: We confirm that ranitidine administration was associated with an increased risk of NEC in preterm infants. H2-blockers use should be only administered in very strictly selected cases after careful consideration of the risk-benefit ratio.

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雷尼替丁治疗对早产儿坏死性小肠结肠炎风险的影响:一项病例对照研究。

胃酸在保护婴儿免受环境中各种病原体的侵害方面起着重要作用。组胺-2受体阻滞剂(h2阻滞剂)是标签外的药物，经常用于早产儿预防应激性溃疡。h2受体阻滞剂对早产儿坏死性小肠结肠炎(NEC)发展的影响仍然存在争议，特别是在发展中国家。材料与方法:122例早产儿纳入研究。采用多变量logistic回归模型确定与NEC相关的潜在产后危险因素。结果:全NEC、内科NEC和外科NEC的早产儿(n = 51)接受雷尼替丁治疗的比例高于对照组(n = 71)(分别为39.2%、19.6%和47.6%，p < 0.05)。Logistic回归分析显示，雷尼替丁的使用和医院感染与NEC的发生显著相关(优势比为1.55和3.3)。结论:我们证实雷尼替丁给药与早产儿NEC风险增加有关。在仔细考虑风险-收益比后，只有在非常严格选择的病例中才能使用h2受体阻滞剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta medica (Hradec Kralove) Medicine-Medicine (all)

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： Acta Medica (Hradec Králové) is a multidisciplinary medical journal published by the Faculty of Medicine in Hradec Králové - Karolinum Press, the publishing house of Charles University. The journal is peer-reviewed and published quarterly in both paper and electronic form. The language of Acta Medica is English. Offerings include review articles, original articles, brief communications, case reports, announcements and notices. The journal was founded in 1958 under the title "A Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove."