The Neuroprotective Properties, Functions, and Roles of Cannabis sativa in Selected Diseases Related to the Nervous System.

Q3 Psychology

Central nervous system agents in medicinal chemistry Pub Date : 2021-01-01 DOI:10.2174/1871524921666210127110028

Onesimus Mahdi, Mohamad T H Baharuldin, Nurul Huda M Nor, Samaila M Chiroma, Saravanan Jagadeesan, Mohamad A M Moklas

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引用次数: 1

Abstract

Background: Cannabis and its extracts are now being explored due to their huge health benefits. Although, the effect they elicit, whether on humans or rodents, may vary based on the age of the animal/subject and or the time in which the extract is administered. However, several debates exist concerning the various medical applications of these compounds. Nonetheless, their applicability as therapeutics should not be clouded based on their perceived negative biological actions.

Methods: Articles from reliable databases such as Science Direct, PubMed, Google Scholar, Scopus, and Ovid were searched. Specific search methods were employed using multiple keywords: ''Medicinal Cannabis; endocannabinoid system; cannabinoids receptors; cannabinoids and cognition; brain disorders; neurodegenerative diseases''. For the inclusion/exclusion criteria, only relevant articles related to medicinal Cannabis and its various compounds were considered.

Results: The current review highlights the role, effects, and involvement of Cannabis, cannabinoids, and endocannabinoids in preventing selected neurodegenerative diseases and possible amelioration of cognitive impairments. Furthermore, it also focuses on Cannabis utilization in many disease conditions such as Alzheimer's and Parkinson's disease among others.

Conclusion: In conclusion, the usage of Cannabis should be further explored as accumulating evidence suggests that it could be effective and somewhat safe, especially when adhered to the recommended dosage. Furthermore, in-depth studies should be conducted in order to unravel the specific mechanism underpinning the involvement of cannabinoids at the cellular level and their therapeutic applications.

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大麻在神经系统相关疾病中的神经保护特性、功能和作用。

背景:由于大麻及其提取物具有巨大的健康益处，目前正在进行探索。然而，它们对人类或啮齿类动物的影响可能会因动物/受试者的年龄和服用提取物的时间而有所不同。然而，关于这些化合物的各种医学应用存在一些争论。尽管如此，它们作为治疗方法的适用性不应因其感知到的负面生物学作用而受到影响。方法:从Science Direct、PubMed、Google Scholar、Scopus、Ovid等可靠的数据库中检索文章。使用多个关键词的特定搜索方法:“药用大麻;神经系统;大麻类受体;大麻素与认知;脑部疾病;神经退行性疾病”。对于纳入/排除标准，只考虑与药用大麻及其各种化合物有关的相关物品。结果:当前的综述强调了大麻、大麻素和内源性大麻素在预防某些神经退行性疾病和可能改善认知障碍方面的作用、作用和参与。此外，它还侧重于在许多疾病条件下使用大麻，如阿尔茨海默病和帕金森病等。结论:综上所述，越来越多的证据表明，大麻的使用可能是有效的，并且在一定程度上是安全的，特别是在坚持推荐剂量的情况下，应该进一步探索大麻的使用。此外，应该进行深入的研究，以揭示大麻素在细胞水平上参与的具体机制及其治疗应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.