Association of maternal blood lead concentration with the risk of small for gestational age: A dose-response meta-analysis.

IF 1.4 4区医学 Q4 ENVIRONMENTAL SCIENCES

Archives of Environmental & Occupational Health Pub Date : 2022-01-01 Epub Date: 2021-01-25 DOI:10.1080/19338244.2021.1874857

Ahmad Habibian Sezavar, Bahman Pourhassan, Nader Rahimi Kakavandi, Mohammad Reza Hooshangi Shayeste, Morteza Abyadeh

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引用次数: 6

Abstract

In spite of growing evidence for the negative effect of lead, knowledge about the dose-response relationship of maternal blood lead level (BLL) and the risk of small for gestational age (SGA) is limited. We performed this meta-analysis to evaluate the dose-response relation between maternal BLL and the risk of SGA. A systematic search through Embase and PubMed was performed. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated. The nonlinear and linear relationships between maternal BLL and the risk of SGA were also investigated. Results from 51,065 patients showed a significant association between maternal BLL and risk of SGA in highest versus lowest analysis (OR: 1.54; 95% CI: 1.12-2.10, p = 0.007). While there was no association in linear dose-response (OR: 1.02; 95% CI: 1.00-1.04, p = 0.021) meta-analysis, a direct relationship was observed in the nonlinear model (nonlinearity p < 0.001). Results of this dose-response meta-analysis showed that maternal BLL higher than ∼ 0.3 µg/dL is directly associated with the risk of SGA.

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母亲血铅浓度与胎龄小风险的关系:一项剂量-反应荟萃分析。

尽管越来越多的证据表明铅的负面影响，关于母亲血铅水平(BLL)和小胎龄(SGA)风险的剂量-反应关系的知识是有限的。我们进行了这项荟萃分析，以评估产妇BLL与SGA风险之间的剂量-反应关系。通过Embase和PubMed进行了系统的搜索。计算优势比(ORs)和95%置信区间(95% CI)。本文还探讨了产妇身体质量与SGA风险之间的非线性和线性关系。51,065例患者的结果显示，在最高和最低分析中，母体BLL与SGA风险之间存在显著关联(OR: 1.54;95% CI: 1.12-2.10, p = 0.007)。而线性剂量反应无相关性(OR: 1.02;95% CI: 1.00-1.04, p = 0.021)，在非线性模型中观察到直接关系(非线性p

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来源期刊

Archives of Environmental & Occupational Health 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： Archives of Environmental & Occupational Health , originally founded in 1919 as the Journal of Industrial Hygiene, and perhaps most well-known as the Archives of Environmental Health, reports, integrates, and consolidates the latest research, both nationally and internationally, from fields germane to environmental health, including epidemiology, toxicology, exposure assessment, modeling and biostatistics, risk science and biochemistry. Publishing new research based on the most rigorous methods and discussion to put this work in perspective for public health, public policy, and sustainability, the Archives addresses such topics of current concern as health significance of chemical exposure, toxic waste, new and old energy technologies, industrial processes, and the environmental causation of disease such as neurotoxicity, birth defects, cancer, and chronic degenerative diseases. For more than 90 years, this noted journal has provided objective documentation of the effects of environmental agents on human and, in some cases, animal populations and information of practical importance on which decisions are based.