The Correlation Between the Autotaxin Enzyme and Pruritus in Egyptian Patients Suffering from Chronic Liver Disease.

Q2 Medicine

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pub Date : 2021-01-01 DOI:10.2174/1871523020666210114092924

Fathia Asal, Dina Ziada, Ayman Wageh, Mohammed El-Kohy, Nehad Hawash, Sherief Abd-Elsalam, Rehab Badawi

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引用次数: 1

Abstract

Background & aims: Pruritus associated with liver diseases confines daily activities and causes sleep deprivation in patients with chronic liver diseases. Autotoxin enzyme (ATX) was found to be higher in sera of patients with intrahepatic cholestasis and it was found to be associated with the intensity of itching. The aim of this study was to assess the correlation between the autotaxin enzyme and pruritus in Egyptian patients suffering from chronic liver disease (CLD).

Methods: This cross-sectional study was carried on a total number of 80 patients with chronic liver disease divided into four groups: Group A and B included cirrhotic patients suffering from pruritis with and without cholestasis, while group C and D included patients without pruritis with or without cholestasis and group E included 17 healthy controls. They were subjected to measurement of serum autotoxin concentration by ELISA in addition to routine investigations including liver function tests: Total and direct bilirubin, ALT, AST, Alkaline phosphatase, Gama- glutamyl transferase, and serum albumin.

Results: There was a significant increase in autotaxin in the four groups included chronic liver disease patients (P-value <0.001*) compared to control group (group E). Autotoxin level was the only marker that had a significant increase in pruritus groups (groups A & B) compared to non-pruritus groups (groups C & D) with cut off value ≥ 32.

Conclusion: Serum autotaxin level was elevated in patients with chronic liver diseases with pruritus. Autotaxin enzyme may play a key role in the induction of hepatogenic pruritus. So, autotaxin enzyme inhibitors and lysophosphatidic acid (LPA) receptor blockers could be a future line of treatment of hepatogenic pruritus.

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埃及慢性肝病患者自体红素酶与瘙痒的关系

背景与目的:慢性肝病患者与肝脏疾病相关的瘙痒限制了日常活动并导致睡眠剥夺。自体毒素酶(ATX)在肝内胆汁淤积症患者血清中较高，且与瘙痒程度相关。本研究的目的是评估埃及慢性肝病(CLD)患者的自体taxin酶与瘙痒症之间的相关性。方法:对80例慢性肝病患者进行横断面研究，分为4组:a组和B组为肝硬化合并瘙痒性炎合并和不合并胆汁淤积的患者，C组和D组为无瘙痒性炎合并和不合并胆汁淤积的患者，E组为17例健康对照。除常规检查包括肝功能检查外，还采用ELISA法测定血清自身毒素浓度:总胆红素和直接胆红素、ALT、AST、碱性磷酸酶、γ -谷氨酰转移酶和血清白蛋白。结果:包括慢性肝病患者在内的四组患者血清autotaxin水平均显著升高(p值)。结论:慢性肝病伴瘙痒患者血清autotaxin水平升高。Autotaxin酶可能在肝源性瘙痒的诱导中起关键作用。因此，自taxin酶抑制剂和溶血磷脂酸(LPA)受体阻滞剂可能是未来治疗肝源性瘙痒的一种方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-inflammatory & anti-allergy agents. Publishing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.