Cytokines in psoriasis.

2区医学 Q1 Chemistry

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-05-23 DOI:10.1016/bs.acc.2020.04.004

Camila Cataldi de Alcantara, Edna Maria Vissoci Reiche, Andréa Name Colado Simão

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引用次数: 15

Abstract

Psoriasis is chronic, immune-mediated, inflammatory disease with a multifactorial etiology that affects the skin tissue and causes the appearance of dry and scaly lesions of anywhere on the body. The study of the pathophysiology of psoriasis reveals a network of immune cells that, together with their cytokines, initiates a chronic inflammatory response. Previously attributed to T helper (Th)1 cytokines, currently the Th17 cytokine family is the major effector in the pathogenesis of psoriatic disease and strongly influences the inflammatory pattern established during the disease activity. In addition, the vast network of cells that orchestrates the pathophysiology makes psoriasis complex to study. Along with this, variations in genes that code the cytokines make psoriasis more clinically heterogeneous and present a challenge for the development of drugs that can be used in the treatment of the patients with this disease. Therefore, it is important to clarify the mechanisms by which the cytokines are involved in the pathophysiology of psoriasis and how this knowledge is translated to the medical practice.

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银屑病中的细胞因子。

牛皮癣是一种慢性、免疫介导的炎症性疾病，具有多因素病因，影响皮肤组织，导致身体任何部位出现干燥和鳞状病变。银屑病的病理生理学研究揭示了一个免疫细胞网络，连同它们的细胞因子，启动慢性炎症反应。以前被认为是辅助性T (Th)1细胞因子，目前Th17细胞因子家族是银屑病发病机制的主要效应因子，并强烈影响疾病活动期间建立的炎症模式。此外，协调病理生理的庞大细胞网络使银屑病的研究变得复杂。与此同时，编码细胞因子的基因变异使牛皮癣在临床上更具异质性，并对可用于治疗该疾病患者的药物的开发提出了挑战。因此，阐明细胞因子参与牛皮癣病理生理的机制以及如何将这些知识转化为医疗实践是很重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Clinical Chemistry 医学-医学实验技术

CiteScore

10.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Clinical Chemistry volumes contain material by leading experts in academia and clinical laboratory science. The reviews cover a wide variety of clinical chemistry disciplines including clinical biomarker exploration, cutting edge microarray technology, proteomics and genomics. It is an indispensable resource and practical guide for practitioners of clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences in general.