Complexity analysis of cold chain transportation in a vaccine supply chain considering activity inspection and time-delay.

Abstract

The development of COVID-19 vaccine is highly concerned by all countries in the world. So far, many kinds of COVID-19 vaccines have entered phase III clinical trial. However, it is difficult to deliver COVID-19 vaccines efficiently and safely to the areas affected by the epidemic. This paper focuses on vaccine transportation in a supply chain model composed of one distributor and one retailer (clinic or hospital), in which the distributor procures COVID-19 vaccines from the manufacturer and then resells them to the retailer. Distributor detects the activity level of the vaccines, and retailer is responsible for transportation of the vaccines. Firstly, we establish a difference equations model with time-delay. Secondly, we investigate the impact of time-delay on the stability of vaccine supply chain. In addition, we explore the influence of decision adjustment speed of the distributor (or retailer) on the stability of vaccine supply chain. Finally, we verify the theoretical results by a two-dimensional bifurcation diagram, the largest Lyapunov exponent, entropy, and domain of attraction. The results show that when the decision delay-time or the adjustment speed of decision variables exceeds a certain threshold, it brings a negative impact on the stability of vaccine supply chain system. The stability domain of the system shrinks as customers' sensitivity to cold chain transportation decreases and by contrast expends as customers' sensitivity to vaccine prices decreases. When the vaccine supply chain is in a state of chaos, the effect of external control over the system is superior to that of internal control over the system.