Improving glucose and lipids metabolism: drug development based on bile acid related targets.

IF 4.1 Q2 CELL BIOLOGY

Cell Stress Pub Date : 2021-01-05 DOI:10.15698/cst2021.01.239

Hanchen Shen, Lili Ding, Mehdi Baig, Jingyan Tian, Yang Wang, Wendong Huang

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引用次数: 8

Abstract

Bariatric surgery is one of the most effective treatment options for severe obesity and its comorbidities. However, it is a major surgery that poses several side effects and risks which impede its clinical use. Therefore, it is urgent to develop alternative safer pharmacological approaches to mimic bariatric surgery. Recent studies suggest that bile acids are key players in mediating the metabolic benefits of bariatric surgery. Bile acids can function as signaling molecules by targeting bile acid nuclear receptors and membrane receptors, like FXR and TGR5 respectively. In addition, the composition of bile acids is regulated by either the hepatic sterol enzymes such as CYP8B1 or the gut microbiome. These bile acid related targets all play important roles in regulating metabolism. Drug development based on these targets could provide new hope for patients without the risks of surgery and at a lower cost. In this review, we summarize the most updated progress on bile acid related targets and development of small molecules as drug candidates based on these targets.

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改善葡萄糖和脂质代谢:基于胆汁酸相关靶点的药物开发。

减肥手术是治疗严重肥胖及其合并症最有效的方法之一。然而，这是一项大手术，有一些副作用和风险，阻碍了它的临床应用。因此，迫切需要开发替代的更安全的药物方法来模拟减肥手术。最近的研究表明，胆汁酸在减肥手术的代谢益处中起着关键作用。胆汁酸可作为信号分子，分别靶向胆汁酸核受体和胆汁酸膜受体，如FXR和TGR5。此外，胆汁酸的组成受到肝脏固醇酶(如CYP8B1)或肠道微生物组的调节。这些胆汁酸相关靶点都在调节代谢中发挥重要作用。基于这些靶点的药物开发可以为患者提供新的希望，无需手术风险，成本更低。本文综述了胆汁酸相关靶点的最新研究进展，以及基于这些靶点的小分子候选药物的开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.