Inter-reader agreement of 18F-FDG PET/CT for the quantification of carotid artery plaque inflammation.

IF 1.5 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
JRSM Cardiovascular Disease Pub Date : 2020-12-15 eCollection Date: 2020-01-01 DOI:10.1177/2048004020980941
Kjersti Johnsrud, Therese Seierstad, David Russell, Mona-Elisabeth Revheim
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引用次数: 3

Abstract

Introduction: A significant proportion of ischemic strokes are caused by emboli from unstable atherosclerotic carotid artery plaques. Inflammation is a key feature of plaque instability. Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-(18F)-fluoro-D-glucose (18F-FDG) is a promising technique to quantify plaque inflammation, but a consensus on the methodology has not been established. High inter-reader agreement is essential if 18F-FDG PET/CT is to be used as a clinical tool for the assessment of unstable plaques and stroke risk.

Methods: We assessed the inter-reader variability of different methods for quantification of 18F-FDG uptake in 43 patients with carotid artery stenosis ≥70%. Two independent readers delineated the plaque and collected maximum standardized uptake value (SUVmax) from all axial PET slices containing the atherosclerotic plaque.

Results: Uptake values with and without background correction were calculated and intraclass correlation coefficients were highest for uncorrected uptake values (0.97-0.98) followed by those background corrected by subtraction (0.89-0.94) and lowest for those background corrected by division (0.74-0.79).

Conclusion: Quantification methods without background correction have the highest inter-reader agreement for 18F-FDG PET of carotid artery plaque inflammation. The use of the single highest uptake value (max SUVmax) from the plaque will facilitate the method's clinical utility in stroke prevention.

Abstract Image

Abstract Image

Abstract Image

18F-FDG PET/CT定量颈动脉斑块炎症的读者间一致。
很大一部分缺血性中风是由不稳定的动脉粥样硬化性颈动脉斑块引起的栓塞引起的。炎症是斑块不稳定的一个关键特征。正电子发射断层扫描/计算机断层扫描(PET/CT)与2-脱氧-2-(18F)-氟-d -葡萄糖(18F- fdg)是一种很有前途的量化斑块炎症的技术,但对方法尚未达成共识。如果18F-FDG PET/CT被用作评估不稳定斑块和卒中风险的临床工具,高度的读者间一致性是必不可少的。方法:我们评估了43例颈动脉狭窄≥70%的患者18F-FDG摄取定量的不同方法的解读器间变异性。两名独立的读者描绘了斑块,并从包含动脉粥样硬化斑块的所有轴向PET切片中收集了最大标准化摄取值(SUVmax)。结果:计算了经背景校正和未经背景校正的摄取值,未校正的摄取值最高(0.97-0.98),其次是经减法校正的摄取值(0.89-0.94),经除法校正的摄取值最低(0.74-0.79)。结论:未经背景校正的定量方法对颈动脉斑块炎症的18F-FDG PET具有最高的读者间一致性。使用单一最高摄取值(最大SUVmax)从斑块将促进该方法在中风预防的临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
JRSM Cardiovascular Disease
JRSM Cardiovascular Disease CARDIAC & CARDIOVASCULAR SYSTEMS-
自引率
6.20%
发文量
12
审稿时长
12 weeks
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