Liver Damage Produced by Malnutrition is Improved by Dietary Supplementation in Mice: Assessment of a Supplement Based on Buriti (A Cerrado Fruit) and Dairy By-products.

Q1 Agricultural and Biological Sciences
Audrey Handyara Bicalho, Fabio Ribeiro do Santos, Daniele Cristina Moreira, Luis Paulo Oliveira, Amanda Souto Machado, Lucyana Farias, Alfredo Mauricio Batista DE Paula, André Luis Sena Guimarães, Sérgio Henrique Sousa Santos
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引用次数: 2

Abstract

Background: Malnutrition induced by dietary restriction produces several metabolic changes that affect body weight, the digestive system, and annex organs, including the liver. Malnutrition generates an inflammatory state and increases oxidative stress. The liver is one of the body vital organs, becoming necessary to analyze the impact of food supplementation on the repair of possible changes that may occur in this organ due to malnutrition.

Aims: To evaluate the effects of a low-cost supplementation derived from Buriti and dairy byproducts on liver recovery in malnourished mice, focusing on the expression of oxidative stressrelated genes, as well as biochemical and histological parameters.

Methods: Swiss mice were divided into six groups and submitted to two treatment phases: food restriction, for malnutrition onset; and renutrition, with mice being fed with different diets.

Results: Our results indicate that dietary supplementation was successful in recovering liver damage caused by malnutrition in animal models. The new supplement has been shown to recover liver damage with similar or superior results compared to the commercial reference supplement on the market.

Conclusion: Our work presents a new composition of low cost food supplement based on buriti and dairy by-products, proven to be effective in the malnutrition treatment of malnutrition. The improvements were proven through the recovery of body weight, reduction of inflammation and oxidative stress.

小鼠营养不良引起的肝损伤可通过膳食补充得到改善:基于Buriti (a Cerrado水果)和乳制品副产品的补充剂的评估。
背景:饮食限制引起的营养不良会产生多种代谢变化,影响体重、消化系统和附属器官,包括肝脏。营养不良会产生炎症状态并增加氧化应激。肝脏是人体重要器官之一,因此有必要分析食物补充对修复由于营养不良可能发生的器官变化的影响。目的:通过观察氧化应激相关基因的表达以及生化和组织学参数,评估低成本的Buriti和乳制品副产品对营养不良小鼠肝脏恢复的影响。方法:将瑞士小鼠分为6组,分为两个治疗阶段:限制食物,治疗营养不良;再营养,用不同的食物喂老鼠。结果:我们的研究结果表明,在动物模型中,膳食补充能够成功地恢复营养不良引起的肝损伤。与市场上的商业参考补充剂相比,新的补充剂已被证明可以恢复肝损伤,效果相似或更好。结论:本研究提出了一种新的低成本食品补充剂组合物,该组合物基于buriti和乳制品副产品,被证明在治疗营养不良方面是有效的。通过体重的恢复、炎症和氧化应激的减少,这些改善得到了证明。
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来源期刊
Recent patents on food, nutrition & agriculture
Recent patents on food, nutrition & agriculture Agricultural and Biological Sciences-Agronomy and Crop Science
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