Relationship Between Oxidative Stress, Tau Level and Antioxidant Mechanisms of the KEAP-1/NRF-2/HO-1 in Children with Hydrocephalus.

Q2 Medicine

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pub Date : 2021-01-01 DOI:10.2174/1871523019666201228111713

Ahmet Guzelcicek, Ismail Koyuncu, Ataman Gönel, Gulyara Cigdem, Mehmet Karadag

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引用次数: 3

Abstract

Background: Hydrocephalus is a complex neurologic disorder that has a widespread impact on the central nervous system and a multifactor disease which affects the CSF dynamics and causes severe neurological impairments in children. The pathophysiology of hydrocephalus is not fully understood. However, increasing evidence suggests that oxidative stress may be an important factor in the pathogenesis of hydrocephalus.

Objective: The purpose of this study is to investigate the relationship of the KEAP-1/NRF-2/HO-1 pathway, one of the main regulators of the antioxidant system in the hydrocephalus pathology, on oxidative stress and tau protein level.

Methods: The study included 32 patients with hydrocephalus and 32 healthy controls. KEAP-1, NRF-2, HO-1, TAU, and MPO levels are measured using ELISA method TAS, TOS, and Total THIOL colorimetric method.

Results: KEAP-1, TAS, and Total THIOL levels were found significantly lowerer in the hydrocephalus group than in the control group. Nevertheless, it was identified that in the hydrocephalus group that the NRF-2, HO-1, TAU, MPO, TOS, and OSI levels were significantly elevated.

Conclusion: In conclusion, although the KEAP-1/NRF-2/HO-1 pathway is activated in patients with hydrocephalus, it is identified that the antioxidant defense system is insufficient and ultimately leads to elevated oxidative stress. The elevation in the tau level may be an indicator of oxidative stress induced neurodegenerative damage.

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脑积水患儿氧化应激、Tau水平与KEAP-1/NRF-2/HO-1抗氧化机制的关系

背景:脑积水是一种广泛影响中枢神经系统的复杂神经系统疾病，是一种影响脑脊液动力学的多因素疾病，可导致儿童严重的神经功能损害。脑积水的病理生理机制尚不完全清楚。然而，越来越多的证据表明，氧化应激可能是脑积水发病的一个重要因素。目的:探讨脑积水病理中抗氧化系统的主要调控因子之一KEAP-1/NRF-2/HO-1通路与氧化应激和tau蛋白水平的关系。方法:选取32例脑积水患者和32例健康对照。KEAP-1、NRF-2、HO-1、TAU和MPO水平采用ELISA法TAS、TOS和总硫醇比色法测定。结果:脑积水组KEAP-1、TAS、Total THIOL水平明显低于对照组。然而，我们发现脑积水组NRF-2、HO-1、TAU、MPO、TOS和OSI水平显著升高。结论:综上所述，脑积水患者虽然KEAP-1/NRF-2/HO-1通路被激活，但确定其抗氧化防御系统不足，最终导致氧化应激升高。tau水平的升高可能是氧化应激诱导的神经退行性损伤的一个指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-inflammatory & anti-allergy agents. Publishing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.