Association between elevated plasma aldosterone concentration and left atrial conduit function in hypertension

Abstract

Aldosterone affects myocardial fibrosis and remodeling. The aim was to investigate the relationship between plasma aldosterone concentration (PAC) and left atrial (LA) function in hypertension. 148 hypertensive patients were studied. LA phasic function was evaluated by strain and strain rate imaging. Patients were divided into two groups based on PAC. LA early diastolic strain and strain rate (LA_S-E and LA_SR-E) were lower in group II compared with group I (P ​< ​0.05). Multivariate regression analysis showed that LA_S-E was independently related to PAC (β ​= ​−0.581, P ​< ​0.001). In conclusion, PAC is associated with LA conduit function in hypertension.