The challenge of primary gastric melanoma: a systematic review.

IF 1 Q4 ONCOLOGY

Melanoma Management Pub Date : 2020-11-23 DOI:10.2217/mmt-2020-0009

Gregory S Mellotte, Diya Sabu, Mary O'Reilly, Ray McDermott, Anthony O'Connor, Barbara M Ryan

引用次数: 0

Abstract

Aim: Primary gastric melanoma is a rare clinical presentation. The purpose of this review was to compare the 1-year survival in patients who underwent surgery with patients who did not receive treatment.

Patients & methods: A systematic search of databases for case reports and case series of primary gastric melanoma was conducted.

Results: The mean survival of patients was 22 months. One-year survival was 56.5% with surgery, rising to 66% with adjuvant therapy. Mean survival of the surgical group was 21.05 months (±20.2) versus 4.5 months (±3.61) in the nonsurgical group.

Conclusion: Primary gastric melanoma has a poor prognosis but early surgical intervention can have a significant impact on patient outcome. We reviewed the biology and clinical diagnosis of gastrointestinal melanoma and the current management options available.

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原发性胃黑色素瘤的挑战：系统综述。

目的：原发性胃黑色素瘤是一种罕见的临床表现。本综述旨在比较接受手术和未接受治疗的患者的 1 年生存率：对数据库中有关原发性胃黑色素瘤的病例报告和系列病例进行了系统检索：患者的平均生存期为22个月。手术组的一年生存率为 56.5%，辅助治疗组的一年生存率上升至 66%。手术组的平均生存期为21.05个月（±20.2）个月，而非手术组为4.5个月（±3.61）个月：原发性胃黑色素瘤预后较差，但早期手术干预对患者预后有显著影响。我们回顾了胃肠道黑色素瘤的生物学特性和临床诊断，以及目前可用的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Melanoma Management ONCOLOGY-

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Skin cancer is on the rise. According to the World Health Organization, 132,000 melanoma skin cancers occur globally each year. While early-stage melanoma is usually relatively easy to treat, once disease spreads prognosis worsens considerably. Therefore, research into combating advanced-stage melanoma is a high priority. New and emerging therapies, such as monoclonal antibodies, B-RAF and KIT inhibitors, antiangiogenic agents and novel chemotherapy approaches hold promise for prolonging survival, but the search for a cure is ongoing. Melanoma Management publishes high-quality peer-reviewed articles on all aspects of melanoma, from prevention to diagnosis and from treatment of early-stage disease to late-stage melanoma and metastasis. The journal presents the latest research findings in melanoma research and treatment, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. Key topics covered include: Risk factors, prevention and sun safety education Diagnosis, staging and grading Surgical excision of melanoma lesions Sentinel lymph node biopsy Biological therapies, including immunotherapy and vaccination Novel chemotherapy options Treatment of metastasis Prevention of recurrence Patient care and quality of life.