G S A Phillips, M Nizamoglu, A Wakure, D Barnes, N El-Muttardi, P Dziewulski
{"title":"The Use Of Dermal Regeneration Templates For Primary Burns Surgery In A UK Regional Burns Centre.","authors":"G S A Phillips, M Nizamoglu, A Wakure, D Barnes, N El-Muttardi, P Dziewulski","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The gold standard of treatment for major burns is early burn excision and autografting. In major burns this is complicated by a lack of donor site availability. Another challenge after burn injury is achieving optimal cosmetic and functional outcomes. Dermal regeneration templates (DRT) are biomatrices that help to address these problems. Within our centre the most commonly used are two-stage Integra® and single-stage Matriderm®. We review the use and outcomes of DRT in primary burns reconstruction within our regional burns centre. All patients undergoing primary burn reconstruction using Integra® (n=59) or Matriderm® (n=35) over a 13-year period were included. Integra® was used in patients with significantly larger burns (20.4% TBSA vs 1.7% TBSA). Comparable levels of graft take were seen in both groups. Major infections were significantly higher in the Integra® group (11/35 compared to 3/59). There was no significant difference in haematoma development, hypertrophic scarring or the need for secondary reconstructive surgery. Burn contractures developed in 15 patients treated with Matriderm® and 21 with Integra®. DRT have been used safely and effectively and have played an increasingly important role in our service over the last 13 years. Integra® is used primarily in large burns with limited donor sites and Matriderm® in smaller burns in cosmetically sensitive areas.</p>","PeriodicalId":8392,"journal":{"name":"Annals of burns and fire disasters","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680195/pdf/Ann-Burns-and-Fire-Disasters-33-245.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of burns and fire disasters","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
The gold standard of treatment for major burns is early burn excision and autografting. In major burns this is complicated by a lack of donor site availability. Another challenge after burn injury is achieving optimal cosmetic and functional outcomes. Dermal regeneration templates (DRT) are biomatrices that help to address these problems. Within our centre the most commonly used are two-stage Integra® and single-stage Matriderm®. We review the use and outcomes of DRT in primary burns reconstruction within our regional burns centre. All patients undergoing primary burn reconstruction using Integra® (n=59) or Matriderm® (n=35) over a 13-year period were included. Integra® was used in patients with significantly larger burns (20.4% TBSA vs 1.7% TBSA). Comparable levels of graft take were seen in both groups. Major infections were significantly higher in the Integra® group (11/35 compared to 3/59). There was no significant difference in haematoma development, hypertrophic scarring or the need for secondary reconstructive surgery. Burn contractures developed in 15 patients treated with Matriderm® and 21 with Integra®. DRT have been used safely and effectively and have played an increasingly important role in our service over the last 13 years. Integra® is used primarily in large burns with limited donor sites and Matriderm® in smaller burns in cosmetically sensitive areas.
治疗严重烧伤的金标准是早期烧伤切除和自体移植。在严重烧伤中,由于供体部位的缺乏,情况变得更加复杂。烧伤后的另一个挑战是获得最佳的外观和功能结果。真皮再生模板(DRT)是一种有助于解决这些问题的生物基质。在我们的中心最常用的是两级Integra®和单级Matriderm®。我们回顾了DRT在我们区域烧伤中心的初级烧伤重建中的使用和结果。所有13年内使用Integra®(n=59)或Matriderm®(n=35)进行初次烧伤重建的患者均被纳入研究。Integra®用于明显较大烧伤的患者(20.4% TBSA vs 1.7% TBSA)。两组患者的移植物摄取量相当。Integra®组的严重感染发生率显著高于前者(11/35比3/59)。在血肿发展、增生性瘢痕或需要二次重建手术方面,两组无显著差异。Matriderm®组15例,Integra®组21例出现烧伤挛缩。在过去的13年里,DRT一直被安全有效地使用,在我们的服务中发挥着越来越重要的作用。Integra®主要用于供体部位有限的大面积烧伤,Matriderm®用于美容敏感区域的较小烧伤。
期刊介绍:
"Annals of Burns and Fire Disasters" is the official publication of the Euro-Mediterranean Council for Burns and Fire Disasters (MBC) and the European Burns Association (EBA). It is a peer-reviewed journal directed to an audience of medical as well as paramedical personnel involved in the management of burn injuries. The journal publishes original articles in the form of clinical and basic research, scientific advances. It publishes also selected abstracts from international journals.