Endocrine Disorders in Pediatric and Adolescent Liver-transplant Recipients.

IF 0.3 Q4 TRANSPLANTATION

International Journal of Organ Transplantation Medicine Pub Date : 2019-01-01

H Ilkhanipoor, M Ahangar Davoodi, S M Dehghani, H Karamifar, S M Abdollahzadeh

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引用次数: 0

Abstract

Background: Particular requirements of pediatric and adolescent liver-transplant (LT) recipients necessitate the evaluation of such population from the endocrine viewpoint.

Objective: To determine the endocrine disorders among LT recipients.

Methods: 129 LT recipients younger than 18 years, and at least 6 months post-LT with no pervious history of endocrine disorders were included in the study. Demographic, anthropometric and biochemical data were collected.

Results: 36% of cases had evidence of impaired fasting glucose; the problem, however, was dramatically resolved (decreased to 2.3%) by using of prediabetic diet. Identifying only 1 case of primary hypothyroidism indicated that thyroid dysfunction seems not to be a prevalent finding in the patients. 3 cases of rickets and no case of parathyroid dysfunction were identified. 11% of the study population were hypocalcemic (2 had rickets as well). Pubertal condition in 3 patients and delayed puberty before LT in 6 remained the same; further evaluation revealed they had hypogonadotropic hypogonadism.

Conclusion: Regular monitoring for development of diabetes and hypocalcemia is indicated. Evaluation of those with delayed puberty for receiving sexual hormones is also recommended.

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儿童和青少年肝移植受者的内分泌紊乱。

背景:儿童和青少年肝移植(LT)受者的特殊需求需要从内分泌角度对这类人群进行评估。目的:了解肝移植受者的内分泌紊乱情况。方法:129例年龄小于18岁、术后至少6个月且既往无内分泌疾病史的肝移植患者纳入研究。收集了人口统计学、人体测量学和生化数据。结果:36%的病例有空腹血糖受损的证据;然而，通过使用糖尿病前期饮食，这个问题得到了显著的解决(降至2.3%)。仅发现1例原发性甲状腺功能减退表明甲状腺功能障碍似乎不是患者的普遍发现。3例佝偻病，无甲状旁腺功能障碍。11%的研究人群患有低钙血症(其中2人患有佝偻病)。3例患者青春期状况不变，6例患者LT前青春期延迟;进一步的评估显示他们患有促性腺激素减退症。结论:应定期监测糖尿病和低钙血症的发展情况。还建议对青春期延迟者接受性激素的情况进行评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Organ Transplantation Medicine TRANSPLANTATION-

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The International Journal of Organ Transplantation Medicine (IJOTM) is a quarterly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research on transplantation. The scope of the journal includes organ and tissue donation, procurement and preservation; surgical techniques, innovations, and novelties in all aspects of transplantation; genomics and immunobiology; immunosuppressive drugs and pharmacology relevant to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses in the field of transplantation; transplant complications; cell and tissue transplantation; infection; post-transplant malignancies; sociological and ethical issues and xenotransplantation.