Angiotensinogen M235T polymorphism and susceptibility to hypertrophic cardiomyopathy in Asian population: A meta analysis.

IF 2.1 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2020-10-01 DOI:10.1177/1470320320978100

Zhen Zhen, Lu Gao, Qin Wang, Xi Chen, Jia Na, Xiwei Xu, Yue Yuan

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Abstract

Objective: To explore the relationship between the polymorphism of angiotensinogen gene (AGT) M235T and susceptibility to hypertrophic cardiomyopathy (HCM) in Asian population by meta-analysis.

Methods: PubMed, Embase, Web of Science, Cochrane library, CNKI, Wan Fang, and other databases were searched to collect the literature about AGT M235T polymorphism and HCM from the inception to March 1, 2020. The Newcastle-Ottawa Scale (NOS) checklist was uesd to perform independent literature review and study quality assessment. Data was analyzed by Stata 15.0 software.

Results: The results showed that, except for the recessive genetic model (TT vs MT+MM: OR = 1.27, 95%CI: 1.05-1.53), in the other four genetic models, the M235T polymorphism had no significant correlation with the risk of HCM (T vs M: OR = 1.17, 95%CI: 0.88-1.57; TT+MT vs MM: OR = 1.13, 95%CI: 0.55-2.33; TT vs MM: OR = 1.25, 95%CI: 0.60-2.59; TM vs MM: OR = 0.95, 95%CI0.5-1.82). The results of subgroup analysis showed that, except for the heterozygous genetic model, in the other four genetic models, M235T polymorphism was significantly associated with sporadic hypertrophic cardiomyopathy (SHCM), but not with familial hypertrophic cardiomyopathy (FHCM) (p > 0.05).

Conclusion: M235T polymorphism in Asians is associated with HCM, especially SHCM. Heterozygotes increase the risk of patients with SHCM.

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亚洲人血管紧张素原 M235T 多态性与肥厚型心肌病的易感性：荟萃分析

目的通过荟萃分析探讨亚洲人群血管紧张素原基因（AGT）M235T多态性与肥厚型心肌病（HCM）易感性之间的关系：方法：检索PubMed、Embase、Web of Science、Cochrane library、CNKI、万方等数据库，收集从开始到2020年3月1日有关AGT M235T多态性与HCM的文献。采用纽卡斯尔-渥太华量表（Newcastle-Ottawa Scale，NOS）核对表进行独立文献综述和研究质量评估。数据由 Stata 15.0 软件进行分析：结果显示，除隐性遗传模型（TT vs MT+MM：OR = 1.27，95%CI：1.05-1.53）外，在其他四种遗传模型中，M235T 多态性与 HCM 风险无显著相关性（T vs M：OR = 1.17，95%CI：0.88-1.57；TT+MT vs MM：OR = 1.13，95%CI：0.55-2.33；TT vs MM：OR = 1.25，95%CI：0.60-2.59；TM vs MM：OR = 0.95，95%CI0.5-1.82）。亚组分析结果显示，除了杂合子遗传模式外，在其他四种遗传模式中，M235T 多态性与散发性肥厚型心肌病（SHCM）显著相关，但与家族性肥厚型心肌病（FHCM）无关（P > 0.05）：结论：亚洲人的 M235T 多态性与 HCM（尤其是 SHCM）有关。结论：亚洲人的 M235T 多态性与 HCM（尤其是 SHCM）有关，杂合子会增加 SHCM 患者的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Renin-Angiotensin-Aldosterone System 医学-外周血管病

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.