Countermeasure and therapeutic: A(1-7) to treat acute respiratory distress syndrome due to COVID-19 infection.

IF 2.1 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
Maira Soto, Gere diZerega, Kathleen E Rodgers
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引用次数: 7

Abstract

In the wake of the COVID-19 pandemic it has become clear that there is a need for therapies that are capable of reducing damage caused to patients from infections. Infections that induce Acute Respiratory Distress Syndrome (ARDS) are especially devastating because lung damage is so critical and difficult to manage. Angiotensin (1-7) [A(1-7)] has already been shown to protect pulmonary health and architecture in various models of disease. There is also evidence that A(1-7) can modulate immune function and protect various organs (lung, kidney, and heart) from oxidative damage and inflammation. Here we focus on making a case for the development of novel therapies that target the protective arm of the Renin Angiotensin System (RAS).

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对策与治疗:A(1-7)治疗COVID-19感染急性呼吸窘迫综合征。
在2019冠状病毒病大流行之后,很明显,需要能够减少感染对患者造成损害的治疗方法。引起急性呼吸窘迫综合征(ARDS)的感染尤其具有破坏性,因为肺损伤非常严重且难以控制。血管紧张素(1-7)[A(1-7)]已被证明在各种疾病模型中保护肺部健康和结构。也有证据表明,A(1-7)可以调节免疫功能,保护各种器官(肺、肾和心脏)免受氧化损伤和炎症。在这里,我们专注于开发针对肾素血管紧张素系统(RAS)保护臂的新疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
16
审稿时长
6-12 weeks
期刊介绍: JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.
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