Pharmacological considerations of antibiotic failures in bovine respiratory disease cases.

IF 4.3 2区 农林科学 Q1 VETERINARY SCIENCES
Animal Health Research Reviews Pub Date : 2020-12-01 Epub Date: 2020-12-02 DOI:10.1017/S1466252320000122
Brian V Lubbers
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引用次数: 0

Abstract

Bovine respiratory disease (BRD) is one of the most common indications for antimicrobial therapy in beef cattle production and research trials demonstrate that antibiotic therapy greatly improves clinical outcome for BRD. These trials also show that BRD treatment success rates are less than 100% and that there are opportunities to optimize antimicrobial prescribing and improve clinical outcomes if the underlying cause(s) of BRD treatment failures can be identified and addressed. As the etiology of BRD in an individual animal is frequently multi-factorial in nature; it is likely that BRD treatment failures also result from complex interactions between the drug, drug administrator, animal host, pathogens, and the environment. This review will focus specifically on the pharmacological aspects, specifically the interactions between the host and the drug and the drug and the drug administrator, of BRD treatment failures and the actions that veterinary practitioners can take to investigate and mitigate therapeutic failures in future cases.

牛呼吸道疾病病例中抗生素失效的药理学考虑。
牛呼吸道疾病(BRD)是肉牛生产中最常见的抗微生物治疗适应症之一,研究试验表明,抗生素治疗可大大改善BRD的临床结果。这些试验还表明,BRD治疗成功率低于100%,如果能够确定和解决BRD治疗失败的根本原因,就有机会优化抗菌药物处方并改善临床结果。由于动物个体BRD的病因通常是多因素的;BRD治疗失败也可能是药物、药物管理者、动物宿主、病原体和环境之间复杂的相互作用造成的。这篇综述将特别关注BRD治疗失败的药理学方面,特别是宿主与药物、药物与药物管理者之间的相互作用,以及兽医从业者在未来病例中可以采取的调查和减轻治疗失败的行动。
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来源期刊
Animal Health Research Reviews
Animal Health Research Reviews VETERINARY SCIENCES-
CiteScore
6.70
自引率
0.00%
发文量
8
期刊介绍: Animal Health Research Reviews provides an international forum for the publication of reviews and commentaries on all aspects of animal health. Papers include in-depth analyses and broader overviews of all facets of health and science in both domestic and wild animals. Major subject areas include physiology and pharmacology, parasitology, bacteriology, food and environmental safety, epidemiology and virology. The journal is of interest to researchers involved in animal health, parasitologists, food safety experts and academics interested in all aspects of animal production and welfare.
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