Anti-inflammatory and immune-modulatory impacts of berberine on activation of autoreactive T cells in autoimmune inflammation.

IF 5.3 2区 医学 Q1 Biochemistry, Genetics and Molecular Biology
Journal of Cellular and Molecular Medicine Pub Date : 2020-12-01 Epub Date: 2020-11-01 DOI:10.1111/jcmm.16049
Seyed-Morteza Ehteshamfar, Masoume Akhbari, Jalil Tavakol Afshari, Motahareh Seyedi, Banafsheh Nikfar, Abbas Shapouri-Moghaddam, Erfan Ghanbarzadeh, Amir Abbas Momtazi-Borojeni
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引用次数: 48

Abstract

Autoreactive inflammatory CD4+ T cells, such as T helper (Th)1 and Th17 subtypes, have been found to associate with the pathogenesis of autoimmune disorders. On the other hand, CD4+ Foxp3+ T regulatory (Treg) cells are crucial for the immune tolerance and have a critical role in the suppression of the excessive immune and inflammatory response promoted by these Th cells. In contrast, dendritic cells (DCs) and macrophages are immune cells that through their inflammatory functions promote autoreactive T-cell responses in autoimmune conditions. In recent years, there has been increasing attention to exploring effective immunomodulatory or anti-inflammatory agents from the herbal collection of traditional medicine. Berberine, an isoquinoline alkaloid, is one of the main active ingredients extracted from medicinal herbs and has been shown to exert various biological and pharmacological effects that are suggested to be mainly attributed to its anti-inflammatory and immunomodulatory properties. Several lines of experimental study have recently investigated the therapeutic potential of berberine for treating autoimmune conditions in animal models of human autoimmune diseases. Here, we aimed to seek mechanisms underlying immunomodulatory and anti-inflammatory effects of berberine on autoreactive inflammatory responses in autoimmune conditions. Reported data reveal that berberine can directly suppress functions and differentiation of pro-inflammatory Th1 and Th17 cells, and indirectly decrease Th cell-mediated inflammation through modulating or suppressing other cells assisting autoreactive inflammation, such as Tregs, DCs and macrophages.

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小檗碱对自身免疫性炎症中自身反应性T细胞活化的抗炎和免疫调节作用。
自身反应性炎症性CD4+ T细胞,如辅助性T细胞(Th)1和Th17亚型,已被发现与自身免疫性疾病的发病机制有关。另一方面,CD4+ Foxp3+ T调节细胞(Treg)对免疫耐受至关重要,在抑制这些Th细胞促进的过度免疫和炎症反应中起着关键作用。相反,树突状细胞(dc)和巨噬细胞是免疫细胞,通过它们的炎症功能促进自身免疫条件下的自身反应性t细胞反应。近年来,人们越来越重视从传统中药中寻找有效的免疫调节或抗炎药物。小檗碱是一种异喹啉类生物碱,是从中草药中提取的主要活性成分之一,已被证明具有多种生物学和药理作用,主要是由于其抗炎和免疫调节特性。最近有几项实验研究调查了小檗碱在人类自身免疫性疾病动物模型中治疗自身免疫性疾病的治疗潜力。在这里,我们旨在寻找小檗碱在自身免疫性疾病中对自身反应性炎症反应的免疫调节和抗炎作用的机制。有报道表明,小檗碱可以直接抑制促炎细胞Th1和Th17的功能和分化,并通过调节或抑制其他辅助自身反应性炎症的细胞,如Tregs、dc和巨噬细胞,间接减少Th细胞介导的炎症。
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来源期刊
CiteScore
10.00
自引率
1.90%
发文量
496
审稿时长
28 weeks
期刊介绍: Bridging physiology and cellular medicine, and molecular biology and molecular therapeutics, Journal of Cellular and Molecular Medicine publishes basic research that furthers our understanding of the cellular and molecular mechanisms of disease and translational studies that convert this knowledge into therapeutic approaches.
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