DNA damaging agents in ovarian cancer

Q3 Medicine

Ejc Supplements Pub Date : 2020-08-01 DOI:10.1016/j.ejcsup.2020.06.001

Maria-Pilar Barretina-Ginesta

引用次数: 2

Abstract

Epithelial ovarian cancer (EOC) is very sensitive to upfront chemotherapy. This condition is attributable to defects in the DNA damage repair system. Agents that damage DNA are the main drugs used for its treatment. Many EOC cells have DNA repair deficiencies that confer susceptibility to these agents. Platinum is the most important agent for first-line and also for relapses, together with other drugs that can be given as monotherapy or along with platinum or other drugs. Lately, the emerging role of PARP inhibitors has changed the landscape of opportunities for patients with EOC. All these strategies will be reviewed in this article.

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卵巢癌中的DNA损伤因子

上皮性卵巢癌(EOC)对前期化疗非常敏感。这种情况可归因于DNA损伤修复系统的缺陷。破坏DNA的药剂是治疗这种疾病的主要药物。许多EOC细胞有DNA修复缺陷，因而对这些药物具有易感性。铂是治疗一线和复发最重要的药物，与其他药物一起使用，可以作为单一疗法，也可以与铂或其他药物一起使用。最近，PARP抑制剂的新作用改变了EOC患者的治疗机会。本文将对所有这些策略进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ejc Supplements 医学-肿瘤学

自引率

0.00%

发文量

审稿时长

3.7 months

期刊介绍： EJC Supplements is an open access companion journal to the European Journal of Cancer. As an open access journal, all published articles are subject to an Article Publication Fee. Immediately upon publication, all articles in EJC Supplements are made openly available through the journal''s websites. EJC Supplements will consider for publication the proceedings of scientific symposia, commissioned thematic issues, and collections of invited articles on preclinical and basic cancer research, translational oncology, clinical oncology and cancer epidemiology and prevention. Authors considering the publication of a supplement in EJC Supplements are requested to contact the Editorial Office of the EJC to discuss their proposal with the Editor-in-Chief. EJC Supplements is an official journal of the European Organisation for Research and Treatment of Cancer (EORTC), the European CanCer Organisation (ECCO) and the European Society of Mastology (EUSOMA).