The hallmarks of ovarian cancer: Focus on angiogenesis and micro-environment and new models for their characterisation

Q3 Medicine

Ejc Supplements Pub Date : 2020-08-01 DOI:10.1016/j.ejcsup.2019.11.003

V. Heredia-Soto , J.A. López-Guerrero , A. Redondo , M. Mendiola

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引用次数: 8

Abstract

Cancers develop by sustained growth, migration and invasion properties of tumour cells, supported by complex interactions with stromal cells within the tumour micro-environment.

This review is focused on the latest discoveries regarding the highlighted role of angiogenesis and tumour micro-environment in ovarian cancer. This cancer milieu encompasses non-cancerous cells present in the tumour or nearby, including vessel-forming cells, fibroblasts and immune cells amongst others that work in a cooperative way with cancer cells, impacting tumour behaviour. Angiogenesis, migration and invasion, and more recently immune evasion, are cancer hallmarks clearly dependent on these supporting cells. Moreover, these stromal cells are more genetically stable than tumour cells and thus represent an attractive therapeutic target. A better understanding of the stromal cells function, and their complex interplay with cancer cells, will open additional areas to target, as the tumour–host interface.

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卵巢癌的特征:关注血管生成和微环境及其表征的新模型。

肿瘤细胞的持续生长、迁移和侵袭特性，以及肿瘤微环境中与基质细胞的复杂相互作用，支持了癌症的发展。本文就血管生成和肿瘤微环境在卵巢癌中的重要作用作一综述。这种癌症环境包括存在于肿瘤或肿瘤附近的非癌细胞，包括血管形成细胞、成纤维细胞和免疫细胞等，它们与癌细胞合作，影响肿瘤的行为。血管生成、迁移和侵袭，以及最近的免疫逃避，都是癌症的标志，显然依赖于这些支持细胞。此外，这些基质细胞在遗传上比肿瘤细胞更稳定，因此是一个有吸引力的治疗靶点。更好地了解基质细胞的功能，以及它们与癌细胞之间复杂的相互作用，将开辟更多的靶点，作为肿瘤-宿主界面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ejc Supplements 医学-肿瘤学

自引率

0.00%

发文量

审稿时长

3.7 months

期刊介绍： EJC Supplements is an open access companion journal to the European Journal of Cancer. As an open access journal, all published articles are subject to an Article Publication Fee. Immediately upon publication, all articles in EJC Supplements are made openly available through the journal''s websites. EJC Supplements will consider for publication the proceedings of scientific symposia, commissioned thematic issues, and collections of invited articles on preclinical and basic cancer research, translational oncology, clinical oncology and cancer epidemiology and prevention. Authors considering the publication of a supplement in EJC Supplements are requested to contact the Editorial Office of the EJC to discuss their proposal with the Editor-in-Chief. EJC Supplements is an official journal of the European Organisation for Research and Treatment of Cancer (EORTC), the European CanCer Organisation (ECCO) and the European Society of Mastology (EUSOMA).