Comparison of Effect of pH Modulation on Wound Healing with Topical Application of Citric Acid Versus Superoxide Ions.

Nigerian Journal of Surgery Pub Date : 2020-07-01 Epub Date: 2020-07-27 DOI:10.4103/njs.NJS_14_19
Sunit Tandon, Baldev Singh, Sudarshan Kapoor, Suruchi Mangal
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引用次数: 8

Abstract

Background: Wound healing is a dynamic process involving tissue repair and regeneration. Nonhealing and chronic wounds are a significant health problem that many patients all over the world are suffering from. Proper wound care is hence very important. Wound dressings have undergone continuous and significant changes over the time period. Optimal dressing should ensure a moist wound bed, help drainage, remove debris, and be anti-allergic and without immunogenicity.

Objectives: The objective of the study is compare the effect of pH modulation on wound healing with topical application of citric acid versus superoxide ions. The aim is to study the efficacy and safety of citric acid versus superoxide ions in the prevention and control of infection and their effect on wound healing in similar wound types.

Materials and methods: We conducted randomized, prospective comparative study in a total of 100 patients admitted at Guru Nanak Dev Hospital, attached to Government Medical College, Amritsar. The patients were divided into two groups: Group A where wound management was done using superoxide ions and Group B where citric acid was used. A standard grading was done in terms of a decrease in wound size, an increase in granulation tissue, and a reduction in wound discharge.

Results: The wounds treated with citric acid showed an average reduction in wound size of 73.43% by the 14th day as compared to 66.52% in the control group. The difference seen in the average reduction of wound size was statistically significant (P = 0.032). The wounds treated by citric acid application showed an average increase in granulation tissue of 56.66% as compared to 50.87% in the wounds treated by superoxide ions. The average hospital stay in patients of Group B was comparatively less than that of patients in Group A.

Conclusion: Citric acid is safe and effective in all types of wound management and gives better efficacy and faster response as compared to superoxide ions. Citric acid promotes wound healing by the formation of granulation tissue and fibroblast proliferation.

柠檬酸与超氧离子局部应用pH调节对伤口愈合的影响比较。
背景:伤口愈合是一个涉及组织修复和再生的动态过程。不愈合和慢性伤口是一个重要的健康问题,世界各地的许多患者都在遭受。因此,适当的伤口护理非常重要。随着时间的推移,伤口敷料经历了持续而重大的变化。最佳敷料应确保伤口床湿润,有助于引流,清除碎片,抗过敏且无免疫原性。目的:本研究的目的是比较pH调节对伤口愈合的影响,局部应用柠檬酸和超氧离子。目的是研究柠檬酸与超氧离子在预防和控制感染中的有效性和安全性及其对类似伤口愈合的影响。材料和方法:我们对阿姆利则政府医学院附属Guru Nanak Dev医院共收治的100例患者进行了随机、前瞻性比较研究。患者分为两组:A组采用超氧离子处理伤口,B组采用柠檬酸处理伤口。根据伤口大小的减少、肉芽组织的增加和伤口排出量的减少进行标准分级。结果:应用柠檬酸治疗的创面在第14天平均缩小73.43%,而对照组平均缩小66.52%。两组平均创面缩小量差异有统计学意义(P = 0.032)。柠檬酸处理的伤口肉芽组织平均增加56.66%,而超氧离子处理的伤口肉芽组织平均增加50.87%。B组患者的平均住院时间相对于a组患者短。结论:柠檬酸在各类创面处理中安全有效,与超氧离子相比疗效更好,反应更快。柠檬酸通过肉芽组织的形成和成纤维细胞的增殖促进伤口愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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