Factors Affecting the Timing of a Central Line Associated Bloodstream Infection Onset in Children with Cancer.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-01-01 Epub Date: 2020-10-26 DOI:10.1177/1043454220966831

Mina Park, Young-Mi Seo, Yoon Jung Shin, Jung Woo Han, Eunhee Cho, Hyeju Jang

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引用次数: 4

Abstract

Purpose: The purpose of this study is to identify controllable treatment-environment-related factors affecting the timing of a central line-associated bloodstream infection (CLABSI) onset in children with cancer with central venous catheters (CVC).

Design: This study is a secondary data analysis with the data extracted from electronic medical records in a tertiary hospital in South Korea. This study was conducted by reviewing electronic medical records of 470 pediatric cancer patients younger than the age of 18 years from 2010 to 2016.

Method: The timing of a CLABSI onset was identified through the onset of CLABSI and the duration of catheterization. Cox proportional hazards regression analysis was used to estimate the impact of variables on the timing of CLABSI onset. The duration of catheterization was estimated using the Kaplan-Meier method.

Finding: Multivariable analysis by Cox proportional model analysis showed that there are six independent variables affecting the timing of a CLABSI onset: length of stay in hospital, catheter insertion location, use of antibiotics on day of catheter insertion, catheter function, number of blood transfusions per 100 days, and number of blood tests per 100 days.

Conclusions: The findings of this study provide a foundation for the development of EBP-based CVC guidelines to effectively reduce CLABSIs and maintain a long-term CVC without a CLABSI.

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影响儿童癌症中央线相关血流感染发病时间的因素

目的:本研究的目的是确定影响中心静脉置管(CVC)儿童癌症中枢线相关血流感染(CLABSI)发病时间的可控治疗环境相关因素。设计:本研究为二次数据分析，数据提取自韩国某三级医院的电子病历。本研究对2010年至2016年期间470名18岁以下儿童癌症患者的电子病历进行了分析。方法:通过CLABSI的发生和置管时间确定CLABSI发生的时间。采用Cox比例风险回归分析估计各变量对CLABSI发病时间的影响。插管时间采用Kaplan-Meier法估计。发现:Cox比例模型多变量分析显示，影响CLABSI发病时间的自变量有6个:住院时间、置管位置、置管当日抗生素使用情况、置管功能、每100天输血次数、每100天验血次数。结论:本研究结果为制定基于ebp的CVC指南提供了基础，以有效减少CLABSI，并在无CLABSI的情况下维持长期CVC。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.