Patient-Reported Outcomes, Experiences and Satisfaction with Weekly and Monthly Injectable Prolonged-Release Buprenorphine.

IF 5.1 Q1 SUBSTANCE ABUSE
Substance Abuse and Rehabilitation Pub Date : 2020-11-02 eCollection Date: 2020-01-01 DOI:10.2147/SAR.S266838
Graham Parsons, Cindy Ragbir, Oscar D'Agnone, Ayana Gibbs, Richard Littlewood, Bernadette Hard
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引用次数: 12

Abstract

Introduction: Prolonged-release buprenorphine (PRB), administered by weekly or monthly injection, for opioid dependence (OD) treatment offers the potential to address some limitations of oral therapy including stigma, difficulty in achieving consistent appropriate dosing, risk of diversion of medications, risk of overdose, and continuing use of other drugs. Patient-reported outcomes (PRO) and experiences are important in the evaluation of OD therapy success. This work aimed to document PRO during PRB therapy to guide future treatment decision-making.

Methods: Qualitative interviews were completed with people on PRB OD treatment. Twenty individuals from four treatment services in England and Wales were asked to participate. A structured interview was developed guided by a person with OD lived experience. Interviews were transcribed, coded and analyzed using iterative categorization.

Results: Fifteen of 20 individuals approached agreed to participate, and 14 completed interviews. The average age of participants was 42 (range 33-54) years, 13 males and 1 woman, the history of problematic opioid use was 14 years (3-25 years), time in treatment was 7 years (1-20 years), and duration on treatment with PRB was 4 months (range 1-8 months). Participants reported treatment experiences leading to coding of 277 unique comments: therapy effectiveness (77% indicated a benefit of, or satisfaction with, PRB therapy, 7% neutral/general, 16% indicated concern or questions about PRB therapy), convenience (81% benefit, 7% neutral/general, 12% concern), and overall satisfaction (81% benefit, 3% neutral/general, 16% concern). Reported benefits include cravings reduction of 10 (71%), self-care improvement of 10 (71%), relationships improvement of 9 (64%), resources management of 6 (43%), positive outlook on life of 12 (86%). Participants reported a range of positive personal experiences; challenges reported included temporary injection discomfort at treatment initiation.

Discussion: In this small, focused population, there was generally a positive level of treatment satisfaction with PRB. These experiences provide insights to explain potential treatment benefit to others and are useful in guiding therapy choices for others in the future.

患者报告的每周和每月注射丁丙诺啡的结果、经验和满意度。
长期释放丁丙诺啡(PRB),每周或每月注射,用于阿片类药物依赖(OD)治疗,提供了解决口服治疗的一些局限性的潜力,包括耻辱,难以达到一致的适当剂量,药物转移的风险,过量的风险,以及继续使用其他药物。患者报告的结果(PRO)和经验是评估OD治疗成功的重要因素。本研究旨在记录PRB治疗过程中的PRO,以指导未来的治疗决策。方法:采用质性访谈法对接受PRB OD治疗的患者进行访谈。来自英格兰和威尔士四家治疗机构的20人被要求参与。在一个有吸毒过量生活经历的人的指导下,进行了一次结构化的访谈。使用迭代分类对访谈进行转录、编码和分析。结果:20个人中有15人同意参与,14人完成了访谈。参与者的平均年龄为42岁(33-54岁),男性13名,女性1名,阿片类药物问题使用史14年(3-25年),治疗时间7年(1-20年),PRB治疗持续时间4个月(1- 8个月)。参与者报告的治疗经历导致277个独特评论的编码:治疗有效性(77%表示对PRB治疗有益或满意,7%中立/一般,16%表示对PRB治疗的关注或问题),便利性(81%受益,7%中立/一般,12%关注)和总体满意度(81%受益,3%中立/一般,16%关注)。报告的益处包括:渴望减少10人(71%),自我照顾改善10人(71%),人际关系改善9人(64%),资源管理改善6人(43%),积极人生观改善12人(86%)。参与者报告了一系列积极的个人经历;报告的挑战包括治疗开始时的暂时性注射不适。讨论:在这个小而集中的人群中,PRB的治疗满意度总体上是积极的。这些经验为解释其他人的潜在治疗益处提供了见解,并有助于指导未来其他人的治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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