INDOLE-3-CARBINOL EXERTS SEX-SPECIFIC EFFECTS IN MURINE COLITIS.

IF 0.7 4区 医学
J M Benson, C A Beamer, B P Seaver, D M Shepherd
{"title":"INDOLE-3-CARBINOL EXERTS SEX-SPECIFIC EFFECTS IN MURINE COLITIS.","authors":"J M Benson,&nbsp;C A Beamer,&nbsp;B P Seaver,&nbsp;D M Shepherd","doi":"10.1177/1721727x1201000309","DOIUrl":null,"url":null,"abstract":"<p><p>Due to the severe adverse effects that can accompany conventional therapies for Crohn's disease, the search for natural complementary therapies has increased dramatically in recent years. Indole-3-carbinol (I3C), a constituent of cruciferous vegetables, possesses anti-inflammatory properties; however, its effects on intestinal inflammation have yet to be evaluated. To test the hypothesis that I3C dampens intestinal inflammation, C57Bl/6 mice were treated with I3C and exposed to 2,4,6-trinitrobenzenesulfonic acid (TNBS) to induce colitis. Several parameters of disease severity and inflammation were subsequently evaluated. I3C dampened the disease severity, as indicated by decreased body weight loss and decreased severity of clinical signs. Interestingly, this effect was observed in female but not male mice, which displayed a trend towards exacerbated colitis. Differential effects were observed in the profiles of cytokine production, as the production of pro-inflammatory cytokines was increased in males. The sex-specific effect of I3C in TNBS-induced colitis is a novel finding and warrants further investigation since this is a common dietary compound and is also available commercially.</p>","PeriodicalId":11913,"journal":{"name":"European Journal of Inflammation","volume":"10 3","pages":"335-346"},"PeriodicalIF":0.7000,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1721727x1201000309","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Inflammation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/1721727x1201000309","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4

Abstract

Due to the severe adverse effects that can accompany conventional therapies for Crohn's disease, the search for natural complementary therapies has increased dramatically in recent years. Indole-3-carbinol (I3C), a constituent of cruciferous vegetables, possesses anti-inflammatory properties; however, its effects on intestinal inflammation have yet to be evaluated. To test the hypothesis that I3C dampens intestinal inflammation, C57Bl/6 mice were treated with I3C and exposed to 2,4,6-trinitrobenzenesulfonic acid (TNBS) to induce colitis. Several parameters of disease severity and inflammation were subsequently evaluated. I3C dampened the disease severity, as indicated by decreased body weight loss and decreased severity of clinical signs. Interestingly, this effect was observed in female but not male mice, which displayed a trend towards exacerbated colitis. Differential effects were observed in the profiles of cytokine production, as the production of pro-inflammatory cytokines was increased in males. The sex-specific effect of I3C in TNBS-induced colitis is a novel finding and warrants further investigation since this is a common dietary compound and is also available commercially.

吲哚-3-甲醇在小鼠结肠炎中具有性别特异性作用。
由于克罗恩病的传统疗法可能伴随严重的副作用,近年来对天然补充疗法的研究急剧增加。吲哚-3-甲醇(I3C)是十字花科蔬菜的一种成分,具有抗炎作用;然而,其对肠道炎症的影响尚未得到评估。为了验证I3C对肠道炎症的抑制作用,我们用I3C治疗C57Bl/6小鼠,同时暴露于2,4,6-三硝基苯磺酸(TNBS)诱导结肠炎。随后评估了疾病严重程度和炎症的几个参数。I3C减轻了疾病的严重程度,这可以通过减轻体重和减轻临床症状的严重程度来证明。有趣的是,这种效应在雌性小鼠中观察到,而在雄性小鼠中没有,雄性小鼠表现出结肠炎加剧的趋势。在细胞因子产生的概况中观察到不同的影响,因为促炎细胞因子的产生在男性中增加。I3C在tnbs诱导的结肠炎中的性别特异性作用是一项新发现,值得进一步研究,因为它是一种常见的膳食化合物,也可以在商业上获得。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
European Journal of Inflammation
European Journal of Inflammation Medicine-Immunology and Allergy
自引率
0.00%
发文量
54
期刊介绍: European Journal of Inflammation is a multidisciplinary, peer-reviewed, open access journal covering a wide range of topics in inflammation, including immunology, pathology, pharmacology and related general experimental and clinical research.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信