Genetic polymorphisms of PGF and TNFAIP2 genes related to cervical cancer risk among Uygur females from China.

4区医学 Q4 Medicine

BMC Medical Genetics Pub Date : 2020-10-27 DOI:10.1186/s12881-020-01144-5

Zumurelaiti Ainiwaer, Reyilanmu Maisaidi, Jing Liu, Lili Han, Sulaiya Husaiyin, Jing Lu, Mayinuer Niyazi

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引用次数: 0

Abstract

Background: PGF and TNFAIP2 are important angiogenic factors, which were abnormal expression in cervical cancer (CC). However, there is currently no report investigating the relationship of PGF and TNFAIP2 gene polymorphisms to CC risk.

Methods: We conducted a case-control study of 342 CC patients and 498 cancer-free controls in a Chinese Uygur female population. Three SNPs (PGF rs8019391, PGF rs2268615, and TNFAIP2 rs710100) were selected and genotyped to assess the possible association of PGF and TNFAIP2 polymorphisms with CC susceptibility. Logistic regression analysis adjusted by age was used.

Results: PGF rs2268615 (OR = 1.39, 95% CI = 1.04-1.86, p = 0.024) and TNFAIP2 rs710100 (OR = 1.44, 95% CI =1.07-1.95, p = 0.018) polymorphisms were associated with the increased risk of CC. Moreover, T allele of PGF rs8019391 was highly represented in patients with stage III-IV compared with stage I-II (OR = 2.17, p = 4.58 × 10^- 4). MDR analysis revealed a positive interaction between the SNPs.

Conclusion: Our data indicated that PGF rs2268615, and TNFAIP2 rs710100 polymorphisms might be risk factors for CC susceptibility, which contributed to the increased risk of CC.

Trial registration: Not applicable.

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PGF 和 TNFAIP2 基因的遗传多态性与中国维吾尔族女性患宫颈癌的风险有关。

背景PGF和TNFAIP2是重要的血管生成因子，在宫颈癌（CC）中表达异常。然而，目前还没有研究 PGF 和 TNFAIP2 基因多态性与 CC 风险关系的报告：我们对中国维吾尔族女性人群中的 342 名 CC 患者和 498 名无癌症对照者进行了病例对照研究。我们选择了三个SNPs（PGF rs8019391、PGF rs2268615和TNFAIP2 rs710100）并进行了基因分型，以评估PGF和TNFAIP2多态性与CC易感性的可能关联。结果显示，PGF rs2268600 和 TNFAIP2 rs710100 多态性与 CC 易感性的相关性：结果：PGF rs2268615（OR = 1.39，95% CI = 1.04-1.86，p = 0.024）和TNFAIP2 rs710100（OR = 1.44，95% CI = 1.07-1.95，p = 0.018）多态性与CC风险增加有关。此外，与 I-II 期患者相比，PGF rs8019391 的 T 等位基因在 III-IV 期患者中的比例较高（OR = 2.17，p = 4.58 × 10-4）。MDR分析显示，SNP之间存在正交互作用：我们的数据表明，PGF rs2268615和TNFAIP2 rs710100多态性可能是CC易感性的危险因素，导致CC风险增加：不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Medical Genetics 医学-遗传学

自引率

0.00%

发文量

审稿时长

12 months

期刊介绍： BMC Medical Genetics is an open access journal publishing original peer-reviewed research articles in the effects of genetic variation in individuals, families and among populations in relation to human health and disease. Note: BMC Medical Genetics is now closed. This journal has merged with BMC Medical Genomics, a broad-scope, open access community journal for all medical genetics and genomics research.