Coronary flow impairment in asymptomatic patients with early stage type-2 diabetes: Detection by FFR_CT.

IF 2.8 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes & Vascular Disease Research Pub Date : 2020-09-01 DOI:10.1177/1479164120958422

Monija Mrgan, Bjarne Linde Nørgaard, Damini Dey, Jørgen Gram, Michael Hecht Olsen, Jeppe Gram, Niels Peter Rønnow Sand

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引用次数: 0

Abstract

Purpose: To determine the occurrence of physiological significant coronary artery disease (CAD) by coronary CT angiography (CTA) derived fractional flow reserve (FFR_CT) in asymptomatic patients with a new diagnosis (<1 year) of type-2 diabetes mellitus (T2DM).

Methods: FFR_CT-analysis was performed from standard acquired coronary CTA data sets. The per-patient minimum distal FFR_CT-value (d-FFR_CT) in coronary vessels (diameter ⩾1.8 mm) was registered. The threshold for categorizing FFR_CT-analysis as abnormal was a d-FFR_CT ⩽0.75. Total plaque volume and volumes of calcified plaque, non-calcified plaque, and low-density non-calcified plaque (LD-NCP) were assessed by quantitative plaque analysis.

Results: Overall, 76 patients; age, mean (SD): 56 (11) years; males, n (%): 49(65), were studied. A total of 57% of patients had plaques. The d-FFR_CT was ⩽0.75 in 12 (16%) patients. The d-FFR_CT, median (IQR), was 0.84 (0.79-0.87). Median (range) d-FFR_CT in patients with d-FFR_CT ⩽0.75 was 0.70 (0.6-0.74). Patients with d-FFR_CT⩽0.75 versus d-FFR_CT >0.75 had numerically higher plaque volumes for all plaques components, although only significant for the LD-NCP component.

Conclusion: Every sixth asymptomatic patient with a new diagnosis of T2DM has hemodynamic significant CAD as evaluated by FFR_CT. Flow impairment by FFR_CT was associated with coronary plaque characteristics.

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早期 2 型糖尿病无症状患者的冠状动脉血流损伤：通过 FFRCT 检测。

目的：通过冠状动脉 CT 血管造影（CTA）得出的分数血流储备（FFRCT），确定新诊断的无症状患者中是否存在生理学意义上的冠状动脉疾病（CAD）：根据标准采集的冠状动脉 CTA 数据集进行 FFRCT 分析。登记冠状动脉血管（直径⩾1.8 毫米）中每位患者的最小远端 FFRCT 值（d-FFRCT）。FFRCT 分析异常的阈值为 d-FFRCT ⩽0.75。通过斑块定量分析评估斑块总体积以及钙化斑块、非钙化斑块和低密度非钙化斑块（LD-NCP）的体积：共有 76 名患者接受了研究；年龄，平均（标清）：56（11）岁；男性，n（%）：49（65）：49（65）人。57%的患者有斑块。12（16%）名患者的 d-FFRCT ⩽0.75。d-FFRCT的中位数（IQR）为0.84（0.79-0.87）。d-FFRCT ⩽0.75患者的d-FFRCT中位数（范围）为0.70（0.6-0.74）。d-FFRCT⩽0.75与d-FFRCT>0.75的患者在所有斑块成分中斑块体积都更大，但只有LD-NCP成分显著：结论：经 FFRCT 评估，每六位新诊断为 T2DM 的无症状患者中就有一位患有血流动力学意义重大的 CAD。FFRCT的血流损伤与冠状动脉斑块的特征有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Vascular Disease Research ENDOCRINOLOGY & METABOLISM-PERIPHERAL VASCULAR DISEASE

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)