Alopecia Areata: A Complex Cytokine Driven Disease

Q2 Medicine

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2020-11-01 DOI:10.1016/j.jisp.2020.04.007

Teresa Song , Emma Guttman-Yassky

引用次数: 1

Abstract

Alopecia areata (AA) has been recently shown to also include T-helper cell type 2/IL-23 activation, in addition to T-helper cell type 1/IFN-skewing. The success of Jak inhibition together with IL-4Rα antagonism and limited response to IL-17A and PDE4 (protein) inhibition in AA are increasing our understanding of the complex immune interplay in AA. Trials testing targeted therapeutics are needed to further elucidate the pathogenic contribution of various cytokines.

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斑秃:一种复杂的细胞因子驱动疾病

斑秃(AA)最近被证明除了t辅助细胞1型/ ifn倾斜外，还包括t辅助细胞2型/IL-23激活。Jak抑制和IL-4Rα拮抗剂的成功以及对IL-17A和PDE4(蛋白)抑制的有限反应增加了我们对AA中复杂免疫相互作用的理解。需要进行靶向治疗的试验，以进一步阐明各种细胞因子的致病作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Investigative Dermatology Symposium Proceedings 医学-皮肤病学

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期刊介绍： Journal of Investigative Dermatology Symposium Proceedings (JIDSP) publishes peer-reviewed, invited papers relevant to all aspects of cutaneous biology and skin disease. Papers in the JIDSP are often initially presented at a scientific meeting. Potential topics include biochemistry, biophysics, carcinogenesis, cellular growth and regulation, clinical research, development, epidemiology and other population-based research, extracellular matrix, genetics, immunology, melanocyte biology, microbiology, molecular and cell biology, pathology, pharmacology and percutaneous absorption, photobiology, physiology, and skin structure.