Loganetin and 5-fluorouracil synergistically inhibit the carcinogenesis of gastric cancer cells via down-regulation of the Wnt/β-catenin pathway.

IF 5.3 2区 医学 Q1 Biochemistry, Genetics and Molecular Biology
Journal of Cellular and Molecular Medicine Pub Date : 2020-12-01 Epub Date: 2020-10-24 DOI:10.1111/jcmm.15932
Huaixiang Zhou, Xiaoge Hu, Na Li, Guangyan Li, Xiaotian Sun, Feimin Ge, Jiahong Jiang, Jingchun Yao, Dongsheng Huang, Liu Yang
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引用次数: 3

Abstract

Although most gastrointestinal tumours are sensitive to 5-fluorouracil (5FU), drug resistance is commonly occurred after 5FU therapy in gastric cancer (GC). Loganetin is the primary active compound in Cornus officinali. However, the synergetic effects of loganetin and 5FU on GC remain unknown. Here, we investigated the synergetic effects and the underlying mechanism of loganetin and 5FU on proliferation, stem-like properties, migration, and invasion of GC both in vitro and in vivo. We found that loganetin alone inhibited the proliferation, stem-like properties, migration and invasion of GC cells in vitro. Importantly, the loganetin remarkably enhanced the anti-cancer effect of 5FU on GC cells and the Wnt/β-catenin pathway might be involved in this process. Animal experiments further confirmed the synergistic effects of 5FU and loganetin on inhibiting cell growth and metastasis of GC. These results suggested that loganetin could synergistically increase the effect of 5FU against GC, which sheds light on effective combinational drug strategies for GC treatment.

Abstract Image

Abstract Image

Abstract Image

马尾草素与5-氟尿嘧啶通过下调Wnt/β-catenin通路协同抑制胃癌细胞的癌变。
虽然大多数胃肠道肿瘤对5-氟尿嘧啶(5FU)敏感,但胃癌(GC)在5FU治疗后通常出现耐药。山茱萸的主要活性成分是龙骨草素。然而,鹿丹素和5FU对GC的协同作用尚不清楚。在此,我们在体外和体内研究了马尾草素和5FU对胃癌的增殖、茎样特性、迁移和侵袭的协同作用及其机制。我们发现,单药对胃癌细胞的增殖、干细胞样特性、迁移和侵袭均有抑制作用。重要的是,马根花素显著增强了5FU对胃癌细胞的抗癌作用,Wnt/β-catenin通路可能参与了这一过程。动物实验进一步证实了5FU与马根皂苷对胃癌细胞生长和转移的协同抑制作用。这些结果表明,马齿苋素可以协同增加5FU对GC的作用,为GC治疗提供了有效的联合药物策略。
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来源期刊
CiteScore
10.00
自引率
1.90%
发文量
496
审稿时长
28 weeks
期刊介绍: Bridging physiology and cellular medicine, and molecular biology and molecular therapeutics, Journal of Cellular and Molecular Medicine publishes basic research that furthers our understanding of the cellular and molecular mechanisms of disease and translational studies that convert this knowledge into therapeutic approaches.
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