Hypothesis: nucleoid-associated proteins segregate with a parental DNA strand to generate coherent phenotypic diversity.

IF 1.3 4区 生物学 Q3 BIOLOGY
Theory in Biosciences Pub Date : 2021-02-01 Epub Date: 2020-10-23 DOI:10.1007/s12064-020-00323-5
Yoan Konto-Ghiorghi, Vic Norris
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引用次数: 2

Abstract

The generation of a phenotypic diversity that is coherent across a bacterial population is a fundamental problem. We propose here that the DNA strand-specific segregation of certain nucleoid-associated proteins or NAPs results in these proteins being asymmetrically distributed to the daughter cells. We invoke a variety of mechanisms as responsible for this asymmetrical segregation including those based on differences between the leading and lagging strands, post-translational modifications, oligomerisation and association with membrane domains.

假设:核相关蛋白与亲本DNA链分离产生一致的表型多样性。
在细菌种群中产生一致的表型多样性是一个基本问题。我们在此提出,某些核相关蛋白或nap的DNA链特异性分离导致这些蛋白不对称地分布到子细胞。我们援引了多种机制来解释这种不对称分离,包括基于前导链和滞后链之间差异的机制、翻译后修饰、寡聚化和与膜结构域的关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Theory in Biosciences
Theory in Biosciences 生物-生物学
CiteScore
2.70
自引率
9.10%
发文量
21
审稿时长
3 months
期刊介绍: Theory in Biosciences focuses on new concepts in theoretical biology. It also includes analytical and modelling approaches as well as philosophical and historical issues. Central topics are: Artificial Life; Bioinformatics with a focus on novel methods, phenomena, and interpretations; Bioinspired Modeling; Complexity, Robustness, and Resilience; Embodied Cognition; Evolutionary Biology; Evo-Devo; Game Theoretic Modeling; Genetics; History of Biology; Language Evolution; Mathematical Biology; Origin of Life; Philosophy of Biology; Population Biology; Systems Biology; Theoretical Ecology; Theoretical Molecular Biology; Theoretical Neuroscience & Cognition.
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