Zebrafish as an Emerging Model System in the Global South: Two Decades of Research in Brazil.

IF 1.4 4区生物学 Q4 DEVELOPMENTAL BIOLOGY

Zebrafish Pub Date : 2020-12-01 Epub Date: 2020-10-20 DOI:10.1089/zeb.2020.1930

Nicholas Silvestre de Souza Trigueiro, Aryelle Canedo, Daniel Lôbo de Siqueira Braga, Ana Carolina Luchiari, Thiago Lopes Rocha

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引用次数: 22

Abstract

The zebrafish (Danio rerio) is an emerging model system in several research areas worldwide, especially in the Global South. In this context, the present study revised the historical use and trends of zebrafish as experimental models in Brazil. The data concerning the bibliometric parameters, research areas, geographic distribution, experimental design, zebrafish strain, and reporter lines, as well as recent advances were revised. In addition, the comparative trends of Brazilian and global research were discussed. Revised data showed the rapid growth of Brazilian scientific production using zebrafish as a model, especially in three main research areas (Neuroscience &and Behavior, Pharmacology and Toxicology, and Environment/Ecology). Studies were conducted in 19 Brazilian states (70.37%), confirming the wide geographic distribution and importance of zebrafish research. Results indicated that research related to toxicological approaches are widespread in Global South countries such as Brazil. Studies were performed mainly using in vivo tests (89.58%) with adult fish (59.75%) and embryos (30.67%). Moreover, significant research gaps and recommendations for future research are presented. The present study shows that the zebrafish is a suitable vertebrate model system in the Global South.

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斑马鱼作为南半球新兴的模式系统:在巴西的二十年研究。

斑马鱼(Danio rerio)是一个新兴的模式系统，在世界范围内的几个研究领域，特别是在全球南方。在此背景下，本研究修订了巴西使用斑马鱼作为实验模型的历史和趋势。对文献计量参数、研究领域、地理分布、实验设计、斑马鱼品系、报告系等数据进行了修订，并对最新进展进行了修订。此外，还讨论了巴西和全球研究的比较趋势。修订后的数据显示，以斑马鱼为模型的巴西科研产量增长迅速，特别是在三个主要研究领域(神经科学与行为学、药理学与毒理学、环境/生态学)。在巴西的19个州(70.37%)进行了研究，证实了斑马鱼研究的广泛地理分布和重要性。结果表明，与毒理学方法有关的研究在巴西等全球南方国家广泛开展。研究主要采用成鱼(59.75%)和胚胎(30.67%)的体内试验(89.58%)。此外，还提出了重大的研究差距和对未来研究的建议。目前的研究表明，斑马鱼是一个合适的脊椎动物模型系统在全球南方。

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来源期刊

Zebrafish DEVELOPMENTAL BIOLOGY-ZOOLOGY

CiteScore

3.60

自引率

5.00%

发文量

审稿时长

3 months

期刊介绍： Zebrafish is the only peer-reviewed journal dedicated to the central role of zebrafish and other aquarium species as models for the study of vertebrate development, evolution, toxicology, and human disease. Due to its prolific reproduction and the external development of the transparent embryo, the zebrafish is a prime model for genetic and developmental studies. While genetically more distant from humans, the vertebrate zebrafish nevertheless has comparable organs and tissues, such as heart, kidney, pancreas, bones, and cartilage. Zebrafish introduced the new section TechnoFish, which highlights these innovations for the general zebrafish community. TechnoFish features two types of articles: TechnoFish Previews: Important, generally useful technical advances or valuable transgenic lines TechnoFish Methods: Brief descriptions of new methods, reagents, or transgenic lines that will be of widespread use in the zebrafish community Zebrafish coverage includes: Comparative genomics and evolution Molecular/cellular mechanisms of cell growth Genetic analysis of embryogenesis and disease Toxicological and infectious disease models Models for neurological disorders and aging New methods, tools, and experimental approaches Zebrafish also includes research with other aquarium species such as medaka, Fugu, and Xiphophorus.