Prognostic Role of Serum Amino Acids in Head and Neck Cancer.

4区 医学 Q3 Medicine
Disease Markers Pub Date : 2020-10-01 eCollection Date: 2020-01-01 DOI:10.1155/2020/2291759
Gabriella Cadoni, Luca Giraldi, Carlo Chiarla, Jacopo Gervasoni, Silvia Persichilli, Aniello Primiano, Stefano Settimi, Jacopo Galli, Gaetano Paludetti, Dario Arzani, Stefania Boccia, Ivo Giovannini, Giovanni Almadori
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引用次数: 15

Abstract

Introduction Serum amino acid (AA) profiles represent a valuable tool in the metabolic assessment of cancer patients; still, information on the AA pattern in head and neck cancer (HNC) patients is insufficient. The aim of the study was to assess whether serum AA levels were associated with the stage of neoplastic disease and prognosis in primary HNC patients. Methods Two hundred and two primary HNC patients were included in the study. Thirty-one AAs and derivatives were measured in serum through an ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). The association between AA concentrations and the stage (advanced versus early) of HNC was estimated using a multivariable logistic regression model. A multivariable Cox regression model was used to evaluate the prognostic significance of each AA. Results At the multivariable logistic regression analysis, increased levels of alpha-aminobutyric acid, aminoadipic acid, histidine, proline, and tryptophan were associated with a reduced risk of advanced stage HNC, while high levels of beta-alanine, beta-aminobutyric acid, ethanolamine, glycine, isoleucine, 4-hydroxyproline, and phenylalanine were associated with an increased risk of advanced stage HNC. Furthermore, at multivariate analysis, increased levels of alpha-aminobutyric acid were associated with increased overall survival (OS), while high levels of arginine, ethanolamine, glycine, histidine, isoleucine, 4-hydroxyproline, leucine, lysine, 3-methylhistidine, phenylalanine, and serine were associated with decreased OS. Conclusions Our study suggests that AA levels are associated with the stage of disease and prognosis in patients with HNC. More study is necessary to evaluate if serum AA levels may be considered a hallmark of HNC and prove to be clinically useful markers of disease status and prognosis in HNC patients.

Abstract Image

血清氨基酸在头颈癌预后中的作用。
简介:血清氨基酸(AA)谱是癌症患者代谢评估的一个有价值的工具;然而,关于头颈癌(HNC)患者AA模式的信息仍然不足。该研究的目的是评估血清AA水平是否与原发性HNC患者的肿瘤疾病分期和预后相关。方法:222例原发性HNC患者纳入研究。采用超高效液相色谱-质谱法(UPLC-MS)测定血清中31种原子吸收剂及其衍生物的含量。使用多变量logistic回归模型估计AA浓度与HNC分期(晚期与早期)之间的关系。采用多变量Cox回归模型评价各AA的预后意义。结果:在多变量logistic回归分析中,α -氨基丁酸、氨基己二酸、组氨酸、脯氨酸和色氨酸水平升高与晚期HNC风险降低相关,而β -丙氨酸、β -氨基丁酸、乙醇胺、甘氨酸、异亮氨酸、4-羟基脯氨酸和苯丙氨酸水平升高与晚期HNC风险增加相关。此外,在多变量分析中,α -氨基丁酸水平升高与总生存期(OS)增加有关,而精氨酸、乙醇胺、甘氨酸、组氨酸、异亮氨酸、4-羟脯氨酸、亮氨酸、赖氨酸、3-甲基组氨酸、苯丙氨酸和丝氨酸水平升高与总生存期(OS)降低有关。结论:我们的研究提示AA水平与HNC患者的疾病分期和预后相关。需要更多的研究来评估血清AA水平是否可以被认为是HNC的标志,并证明是HNC患者疾病状态和预后的临床有用标记。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Disease Markers
Disease Markers 医学-病理学
自引率
0.00%
发文量
792
审稿时长
6-12 weeks
期刊介绍: Disease Markers is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the identification of disease markers, the elucidation of their role and mechanism, as well as their application in the prognosis, diagnosis and treatment of diseases.
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