Sex Differences in Substance Use and Misuse: A Toxicology Investigators' Consortium (ToxIC) Registry Analysis.

IF 5.1 Q1 SUBSTANCE ABUSE
Substance Abuse and Rehabilitation Pub Date : 2020-09-29 eCollection Date: 2020-01-01 DOI:10.2147/SAR.S263165
Gillian A Beauchamp, Jennifer L Carey, Mikayla B Hurwitz, Briana N Tully, Matthew D Cook, Robert D Cannon, Kenneth D Katz, Andrew L Koons, Hope Kincaid, Marna Rayl Greenberg
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Abstract

Background: Variations between male and female populations are previously reported in classes of harmfully used/misused drugs, severity of substance use disorder and risk of relapse. The aim of this study was to provide a review of bedside medical toxicologist managed, sex-specific poisonings in adults that present with harmful drug use/misuse.

Methods: ToxIC Registry cases ≥19 and ≤65 years old, with harmful drug use or misuse during the timeframe June 2010-December 2016, were studied. Demographics, primary agents of toxic exposure, administration route and complications were analyzed. Descriptive methods were used in the analysis.

Results: The database included 51,440 cases. Of these, 3426 cases were analyzed in which the primary reason for the encounter was harmful substance use/misuse. Females were found to harmfully use/misuse pharmaceutical drugs (N=806, 65.6%) more than nonpharmaceutical drugs (N=423, 34.4%). Males more frequently used nonpharmaceutical drugs (N=1189, 54.1%) than pharmaceutical drugs (1008, 45.9%). Analgesics were used by females (N= 215, 18.2%) and males (N=137, 6.6%). Sedative hypnotics were used by females (N=165, 14%) and males (N=160, 7.8%). Psychoactive agents were used by males (N=325, 15.8%) and females (N=67, 5.7%). Sympathomimetics were used by males (N=381, 18.5%) and females (N=151, 12.8%). The majority of both male and female participants, 1712 (57.9%), utilized an oral route of administration. However, 312 (16.5%) of males utilized inhalation vs 73 (6.8%) of females inhaled their substance.

Conclusion: There were sex-specific differences among patients evaluated for harmful substance use/misuse by toxicologists. Considering these differences in regards to management and preventive approaches may be indicated.

Abstract Image

物质使用和滥用的性别差异:毒理学调查协会(毒性)登记分析。
背景:男性和女性人群在有害使用/滥用药物类别、物质使用障碍严重程度和复发风险方面的差异先前有过报道。本研究的目的是对床边医学毒理学家管理的、因有害药物使用/滥用而导致的成人性别特异性中毒进行综述。方法:选取2010年6月至2016年12月期间毒性登记≥19岁,≤65岁,有有害药物使用或误用的病例。分析患者的人口统计学特征、主要中毒因素、给药途径及并发症。分析采用描述性方法。结果:数据库包括51440例病例。其中,分析了3426个案例,其中遭遇的主要原因是有害物质的使用/滥用。女性有害使用/误用药物(N=806, 65.6%)多于非药物(N=423, 34.4%)。男性非药物使用频率(1189,54.1%)高于药物使用频率(1008,45.9%)。女性215例(18.2%),男性137例(6.6%)。女性165例,占14%;男性160例,占7.8%。男性(N=325, 15.8%)和女性(N=67, 5.7%)使用精神活性药物。男性(N=381, 18.5%)和女性(N=151, 12.8%)采用拟交感神经。大多数男性和女性参与者,1712(57.9%),采用口服给药途径。然而,312名(16.5%)男性使用吸入法,而73名(6.8%)女性使用吸入法。结论:毒理学家评估的有害物质使用/滥用患者存在性别差异。考虑到在管理和预防办法方面的这些差异,可能需要指出。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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