Development of tannic acid-enriched materials modified by poly(ethylene glycol) for potential applications as wound dressing.

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Progress in Biomaterials Pub Date : 2020-09-01 Epub Date: 2020-09-20 DOI:10.1007/s40204-020-00136-1
Beata Kaczmarek, Olha Mazur, Oliwia Miłek, Marta Michalska-Sionkowska, Anna M Osyczka, Konrad Kleszczyński
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引用次数: 12

Abstract

The interests in the biomedical impact of tannic acid (TA) targeting production of various types of biomaterials, such as digital microfluids, chemical sensors, wound dressings, or bioimplants constantly increase. Despite the significant disadvantage of materials obtained from natural-based compounds and their low stability and fragility, therefore, there is an imperative need to improve materials properties by addition of stabilizing formulas. In this study, we performed assessments of thin films over TA proposed as a cross-linker to be used in combination with polymeric matrix based on chitosan (CTS), i.e. CTS/TA at 80:20 or CTS/TA at 50:50 and poly(ethylene glycol) (PEG) at the concentration of 10% or 20%. We evaluated their mechanical parameters as well as the cytotoxicity assay for human bone marrow mesenchymal stem cells, human melanotic melanoma (MNT-1), and human osteosarcoma (Saos-2). The results revealed significant differences in dose-dependent of PEG regarding the maximum tensile strength (σmax) or impact on the metabolic activity of tissue culture plastic. We observed that PEG improved mechanical parameters prominently, decreased the hemolysis rate, and did not affect cell viability negatively. Enclosed data, confirmed also by our previous reports, will undoubtedly pave the path for the future application of tannic acid-based biomaterials to treat wound healing.

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聚乙二醇改性富单宁酸材料在创面敷料中的应用前景。
对单宁酸(TA)的生物医学影响的兴趣不断增加,其目标是生产各种类型的生物材料,如数字微流体、化学传感器、伤口敷料或生物植入物。尽管从天然化合物中获得的材料具有明显的缺点,并且它们的稳定性和易碎性较低,因此,迫切需要通过添加稳定配方来改善材料的性能。在本研究中,我们评估了将TA作为交联剂的薄膜与基于壳聚糖(CTS)的聚合物基体(CTS /TA为80:20或CTS/TA为50:50,聚乙二醇(PEG)为10%或20%)结合使用的效果。我们评估了它们的力学参数以及对人骨髓间充质干细胞、人黑色素瘤(MNT-1)和人骨肉瘤(Saos-2)的细胞毒性测定。结果表明,聚乙二醇的最大抗拉强度(σmax)和对组织培养塑料代谢活性的影响存在剂量依赖性。我们观察到PEG显著改善了机械参数,降低了溶血率,并且对细胞活力没有负面影响。所附的数据,也被我们之前的报告证实,无疑将为未来应用单宁酸基生物材料治疗伤口愈合铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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