Molecular Pathogenesis and Classification of Colorectal Carcinoma.

Q3 Medicine

Current Colorectal Cancer Reports Pub Date : 2020-09-01 Epub Date: 2020-08-15 DOI:10.1007/s11888-020-00458-z

Anup Kasi, Shivani Handa, Sajjad Bhatti, Shahid Umar, Ajay Bansal, Weijing Sun

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引用次数: 10

Abstract

Purpose of review: Molecular pathways in colorectal carcinogenesis involve several complex genetic and epigenetic modulations that cause normal colonic mucosa to metamorphose into a benign polyp and subsequently into a malignant tumor. Our purpose is to recapitulate historical and recent genomic research in order to augment the understanding of colorectal cancer pathogenesis.

Recent findings: In 2015, the molecular classification for colorectal cancers was unified into one system with four distinct groups, also called as consensus molecular subtypes. This led to an enhanced understanding of molecular and immune signatures which has implications on predicting the clinical behavior as well as response to different therapeutic agents.

Summary: In this review, we expound on the current literature as well as draw on our own experience to present the important molecular pathogenesis pathways, key genetic mutations, differences in pathogenesis of left versus right sided tumors as well as the molecular classification of colorectal cancers.

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结直肠癌的分子发病机制及分类。

综述目的:大肠癌发生的分子途径涉及多种复杂的遗传和表观遗传调控，这些调控可导致正常结肠黏膜蜕变为良性息肉，进而演变为恶性肿瘤。我们的目的是概述历史和最近的基因组研究，以增加对结直肠癌发病机制的理解。近期发现:2015年，结直肠癌的分子分类被统一为一个系统，分为四个不同的组，也称为共识分子亚型。这导致了对分子和免疫特征的增强理解，这对预测临床行为以及对不同治疗剂的反应具有重要意义。摘要:本文在对现有文献进行阐述的基础上，结合自身经验，对结直肠癌的重要分子发病途径、关键基因突变、左右侧肿瘤的发病差异以及结直肠癌的分子分类进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Colorectal Cancer Reports ONCOLOGY-

自引率

0.00%

发文量

期刊介绍： This journal aims to review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of colorectal cancer. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those with the disease. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and emerging therapeutic approaches and the molecular basis of disease. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.