The Association Between Chronic Kidney Disease and New Onset Renal Replacement Therapy on the Outcome of COVID-19 Patients: A Meta-analysis.

IF 1 Q4 RESPIRATORY SYSTEM

Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine Pub Date : 2020-09-17 eCollection Date: 2020-01-01 DOI:10.1177/1179548420959165

Raymond Pranata, Rudi Supriyadi, Ian Huang, Hikmat Permana, Michael Anthonius Lim, Emir Yonas, Nanny Natalia M Soetedjo, Antonia Anna Lukito

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引用次数: 43

Abstract

Objective: The aim of the study was to evaluate the association between chronic kidney disease (CKD) and new onset renal replacement therapy (RRT) with the outcome of Coronavirus Disease 2019 (COVID-19) in patients.

Methodology: A systematic literature search from several databases was performed on studies that assessed CKD, use of RRT, and the outcome of COVID-19. The composite of poor outcome consisted of mortality, severe COVID-19, acute respiratory distress syndrome (ARDS), need for intensive care, and use of mechanical ventilator.

Results: Nineteen studies with a total of 7216 patients were included. CKD was associated with increased composite poor outcome (RR 2.63 [1.33, 5.17], P = .03; I ² = 51%, P = .01) and its subgroup, consisting of mortality (RR 3.47 [1.36, 8.86], P = .009; I ² = 14%, P = .32) and severe COVID-19 (RR 2.89 [0.98, 8.46], P = .05; I ² = 57%, P = .04). RRT was associated with increased composite poor outcome (RR 18.04 [4.44, 73.25], P < .001; I ² = 87%, P < .001), including mortality (RR 26.02 [5.01, 135.13], P < .001; I ² = 60%, P = .06), severe COVID-19 (RR 12.95 [1.93, 86.82], P = .008; I ² = 81%, P < .001), intensive care (IC) (RR 14.22 [1.76, 114.62], P < .01; I ² = 0%, P < .98), and use of mechanical ventilator (RR 34.39 [4.63, 255.51], P < .0005).

Conclusion: CKD and new-onset RRT were associated with poor outcome in patients with COVID-19.

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慢性肾脏疾病和新发肾脏替代治疗对COVID-19患者预后的相关性:一项荟萃分析

目的:本研究旨在评估慢性肾脏疾病(CKD)和新发肾脏替代治疗(RRT)与2019冠状病毒病(COVID-19)患者预后的关系。方法:从多个数据库中对评估CKD、RRT使用和COVID-19结局的研究进行了系统的文献检索。不良预后的组合包括死亡率、严重COVID-19、急性呼吸窘迫综合征(ARDS)、需要重症监护和使用机械呼吸机。结果:19项研究共纳入7216例患者。CKD与综合不良预后增加相关(RR 2.63 [1.33, 5.17]， P = .03;I 2 = 51%， P = 0.01)及其亚组，包括死亡率(RR 3.47 [1.36, 8.86]， P = 0.009;我2 = 14%,P = 32)严重COVID-19 (RR 2.89 [0.98, 8.46], P = . 05;I 2 = 57%， p = .04)。RRT与综合不良预后增加(RR 18.04 [4.44, 73.25]， p2 = 87%， p2 = 60%， P = 0.06)、重症COVID-19 (RR 12.95 [1.93, 86.82]， P = 0.008;结论:CKD和新发RRT与COVID-19患者预后不良相关。

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