Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia.

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2020-01-01 Epub Date: 2020-05-23 DOI:10.1515/pteridines-2020-0012

Katelynn A Bourassa, Teodor T Postolache, Aline Dagdag, Dietmar Fuchs, Olaoluwa O Okusaga

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引用次数: 4

Abstract

Background: Soluble P-selectin (sP-selectin) is associated with risk factors for cardiovascular disease (CVD) but this association has not been evaluated in patients with schizophrenia. This study primarily evaluated the association of sP-selectin with plasma lipids and nitrite (NO₂-) respectively in overweight/obese adults with schizophrenia.

Methods: One-hundred and six patients with schizophrenia (mean age 32.9 years; 71.60% male) were recruited from a psychiatric hospital. Participants completed a structured interview and provided a fasting blood sample. Body mass index (BMI) was used to divide the sample into normal weight and overweight/obese groups. Pearson's and partial correlation coefficients (controlling for age, sex, race, education, and inflammation) were calculated to examine the association of sP-selectin with plasma lipids, and NO₂- in the overweight/obese patients (primary analysis), as well as in the normal weight patients and the total sample (exploratory analyses).

Results: After controlling for potential confounders, sP-selectin positively correlated with triglycerides (r = 0.38, p = 0.01) and NO₂- (r = 0.40, p < 0.01) in the overweight/obese group only.

Conclusions: Future longitudinal studies should evaluate the utility of sP-selectin as a biomarker of CVD in overweight/obese adults with schizophrenia (for example, by relating sP-selectin to incidence of cardiovascular events).

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超重/肥胖精神分裂症患者血浆可溶性p选择素与甘油三酯和亚硝酸盐相关

背景:可溶性p -选择素(sp -选择素)与心血管疾病(CVD)的危险因素相关，但这种关联尚未在精神分裂症患者中得到评估。本研究主要评估了sp -选择素与超重/肥胖成人精神分裂症患者血脂和亚硝酸盐(NO2-)的关系。方法:106例精神分裂症患者(平均年龄32.9岁;(71.60%男性)从精神病院招募。参与者完成了一个结构化的访谈，并提供了空腹血液样本。使用身体质量指数(BMI)将样本分为正常体重组和超重/肥胖组。计算Pearson和偏相关系数(控制年龄、性别、种族、教育程度和炎症)，以检验超重/肥胖患者(初步分析)以及正常体重患者和总样本(探索性分析)中sp -选择素与血浆脂质和NO2-的关系。结果:在控制潜在混杂因素后，sP-selectin仅在超重/肥胖组与甘油三酯(r = 0.38, p = 0.01)和NO2- (r = 0.40, p < 0.01)呈正相关。结论:未来的纵向研究应该评估sp -选择素作为超重/肥胖精神分裂症成人CVD生物标志物的效用(例如，通过将sp -选择素与心血管事件发生率联系起来)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.