Lipid-Induced Mechanisms of Metabolic Syndrome.

IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM
Journal of Obesity Pub Date : 2020-08-26 eCollection Date: 2020-01-01 DOI:10.1155/2020/5762395
Yulia K Denisenko, Oxana Yu Kytikova, Tatyana P Novgorodtseva, Marina V Antonyuk, Tatyana A Gvozdenko, Tatyana A Kantur
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引用次数: 28

Abstract

Metabolic syndrome (MetS) has a worldwide tendency to increase and depends on many components, which explains the complexity of diagnosis, approaches to the prevention, and treatment of this pathology. Insulin resistance (IR) is the crucial cause of the MetS pathogenesis, which develops against the background of abdominal obesity. In light of recent evidence, it has been shown that lipids, especially fatty acids (FAs), are important signaling molecules that regulate the signaling pathways of insulin and inflammatory mediators. On the one hand, the lack of n-3 polyunsaturated fatty acids (PUFAs) in the body leads to impaired molecular mechanisms of glucose transport, the formation of unresolved inflammation. On the other hand, excessive formation of free fatty acids (FFAs) underlies the development of oxidative stress and mitochondrial dysfunction in MetS. Understanding the molecular mechanisms of the participation of FAs and their metabolites in the pathogenesis of MetS will contribute to the development of new diagnostic methods and targeted therapy for this disease. The purpose of this review is to highlight recent advances in the study of the effect of fatty acids as modulators of insulin response and inflammatory process in the pathogenesis and treatment for MetS.

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脂质诱导代谢综合征的机制。
代谢综合征(MetS)在世界范围内有增加的趋势,这取决于许多因素,这解释了这种病理的诊断、预防和治疗方法的复杂性。胰岛素抵抗(Insulin resistance, IR)是met发病的重要原因,是在腹部肥胖的背景下发展起来的。根据最近的证据,脂质,特别是脂肪酸(FAs)是调节胰岛素和炎症介质信号通路的重要信号分子。一方面,体内缺乏n-3多不饱和脂肪酸(PUFAs)会导致葡萄糖运输的分子机制受损,形成无法解决的炎症。另一方面,游离脂肪酸(FFAs)的过度形成是MetS中氧化应激和线粒体功能障碍发展的基础。了解FAs及其代谢物参与MetS发病的分子机制将有助于开发新的诊断方法和靶向治疗方法。这篇综述的目的是强调脂肪酸作为胰岛素反应和炎症过程的调节剂在MetS的发病机制和治疗中的作用的最新研究进展。
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来源期刊
Journal of Obesity
Journal of Obesity ENDOCRINOLOGY & METABOLISM-
CiteScore
7.50
自引率
3.00%
发文量
19
审稿时长
21 weeks
期刊介绍: Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.
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